Immunologic Monitoring in Kidney Transplant Recipients

Overview

Journal Kidney Res Clin Pract

Specialty Nephrology

Date 2016 Feb 16

PMID 26877913

Citations 5

Authors

Natavudh Townamchai

Kassem Safa

Anil Chandraker

Affiliations

Soon will be listed here.

Abstract

Transplant biopsy has always been the gold standard for assessing the immune response to a kidney allograft (Chandraker A: Diagnostic techniques in the work-up of renal allograft dysfunction-an update. Curr Opin Nephrol Hypertens 8:723-728, 1999). A biopsy is not without risk and is unable to predict rejection and is only diagnostic once rejection has already occurred. However, in the past two decades, we have seen an expansion in assays that can potentially put an end to the "drug level" era, which until now has been one of the few tools available to clinicians for monitoring the immune response. A better understanding of the mechanisms of rejection and tolerance, and technological advances has led to the development of new noninvasive methods to monitor the immune response. In this article, we discuss these new methods and their potential uses in renal transplant recipients.

Citing Articles

Proteomics for Biomarker Discovery for Diagnosis and Prognosis of Kidney Transplantation Rejection.

Ramalhete L, Araujo R, Ferreira A, Calado C Proteomes. 2022; 10(3).

PMID: 35893765 PMC: 9326686. DOI: 10.3390/proteomes10030024.

High-Throughput Sequencing of Complementarity Determining Region 3 in the Heavy Chain of B-Cell Receptor in Renal Transplant Recipients: A Preliminary Report.

Wu T, Liao H, Li T, Tsai H, Lin N, Chen C J Clin Med. 2022; 11(11).

PMID: 35683373 PMC: 9181060. DOI: 10.3390/jcm11112980.

Emerging monitoring technologies in kidney transplantation.

Ehlayel A, Simms K, Ashoor I Pediatr Nephrol. 2021; 36(10):3077-3087.

PMID: 33523298 DOI: 10.1007/s00467-021-04929-9.

Immunosuppression-related neurological disorders in kidney transplantation.

Faravelli I, Velardo D, Podesta M, Ponticelli C J Nephrol. 2021; 34(2):539-555.

PMID: 33481222 PMC: 8036223. DOI: 10.1007/s40620-020-00956-1.

Increased Circulating T Lymphocytes Expressing HLA-DR in Kidney Transplant Recipients with Microcirculation Inflammation.

Jung H, Kim Y, Choi J, Cho J, Park S, Kim Y J Korean Med Sci. 2017; 32(6):908-918.

PMID: 28480647 PMC: 5426246. DOI: 10.3346/jkms.2017.32.6.908.

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