Role of a Liver-first Approach for Synchronous Colorectal Liver Metastases

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2016 Feb 16

PMID 26877617

Citations 5

Authors

Kun Wang

Wei Liu

Xiao-Luan Yan

Bao-Cai Xing

Affiliations

Soon will be listed here.

Abstract

Aim: To evaluate the feasibility and survival outcomes of a liver-first approach.

Methods: Between January 2009 and April 2013, 18 synchronous colorectal liver metastases (sCRLMs) patients with a planned liver-first approach in the Hepatopancreatobiliary Surgery Department I of the Beijing Cancer Hospital were enrolled in this study. Clinical data, surgical outcomes, morbidity and mortality rates were collected. The feasibility and long-term outcomes of the approach were retrospectively analyzed.

Results: Sixteen patients (88.9%) completed the treatment protocol for primary and liver tumors. The main reason for treatment failure was liver disease recurrence. The 1 and 3 year overall survival rates were 94.4% and 44.8%, respectively. The median survival time was 30 mo. The postoperative morbidity and mortality were 22.2% and 0%, respectively, following a hepatic resection, and were 18.8% and 0%, respectively, after a colorectal surgery.

Conclusion: The liver-first approach appeared to be feasible and safe. It can be performed with a comparable mortality and morbidity to the traditional treatment paradigm. This approach might offer a curative opportunity for sCRLM patients with a high liver disease burden.

Citing Articles

Liver-first approach to the treatment of patients with synchronous colorectal liver metastases: a systematic review and meta-analysis.

Bulisani B, Leite M, Waisberg J Einstein (Sao Paulo). 2024; 22:eRW0596.

PMID: 39661858 PMC: 11634356. DOI: 10.31744/einstein_journal/2024RW0596.

Feasibility and Short-Term Outcomes in Liver-First Approach: A Spanish Snapshot Study (the RENACI Project).

Serradilla-Martin M, Villodre C, Falgueras-Verdaguer L, Zambudio-Carroll N, Castell-Gomez J, Blas-Laina J Cancers (Basel). 2024; 16(9).

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A Liver-First Approach Using Ablation for Oligometastatic Pancreatic Cancer: A Report of a Successful Case.

Ikuta S, Nakajima T, Aihara T, Fujikawa M, Yamanaka N Cureus. 2023; 15(10):e46671.

PMID: 37942384 PMC: 10628600. DOI: 10.7759/cureus.46671.

A narrative review of intraoperative use of indocyanine green fluorescence imaging in gastrointestinal cancer: situation and future directions.

Li H, Xie X, Du F, Zhu X, Ren H, Ye C J Gastrointest Oncol. 2023; 14(2):1095-1113.

PMID: 37201097 PMC: 10186510. DOI: 10.21037/jgo-23-230.

Hepatic Metastasis from Colorectal Cancer.

Valderrama-Trevino A, Barrera-Mera B, Ceballos-Villalva J, Montalvo-Jave E Euroasian J Hepatogastroenterol. 2017; 7(2):166-175.

PMID: 29201802 PMC: 5670263. DOI: 10.5005/jp-journals-10018-1241.

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