» Articles » PMID: 26876902

Recent Progress in Cell Reprogramming Technology for Cell Transplantation Therapy

Overview
Specialties Neurology
Neurosurgery
Date 2016 Feb 16
PMID 26876902
Citations 1
Authors
Affiliations
Soon will be listed here.
Abstract

The discovery of induced pluripotent stem (iPS) cells opened the gate for reprogramming technology with which we can change the cell fate through overexpression of master transcriptional factors. Now we can prepare various kinds of neuronal cells directly induced from somatic cells. It has been reported that overexpression of a neuron-specific transcriptional factors might change the cell fate of endogenous astroglia to neuronal cells in vivo. In addition, some research groups demonstrated that chemical compound can induce chemical-induced neuronal cells, without transcriptional factors overexpression. In this review, we briefly review recent progress in the induced neuronal (iN) cells, and discuss the possibility of application for cell transplantation therapy.

Citing Articles

Rad51 Regulates Reprogramming Efficiency through DNA Repair Pathway.

Lee J, Kim D, Ko J, Kim K, Park K Dev Reprod. 2016; 20(2):163-9.

PMID: 27660832 PMC: 5027222. DOI: 10.12717/DR.2016.20.2.163.

References
1.
Hong J, Lee S, Lee S, Kim J, Kim K, Kim S . Therapeutic potential of induced neural stem cells for spinal cord injury. J Biol Chem. 2014; 289(47):32512-25. PMC: 4239606. DOI: 10.1074/jbc.M114.588871. View

2.
Tanna T, Sachan V . Mesenchymal stem cells: potential in treatment of neurodegenerative diseases. Curr Stem Cell Res Ther. 2014; 9(6):513-21. DOI: 10.2174/1574888x09666140923101110. View

3.
Hu W, Qiu B, Guan W, Wang Q, Wang M, Li W . Direct Conversion of Normal and Alzheimer's Disease Human Fibroblasts into Neuronal Cells by Small Molecules. Cell Stem Cell. 2015; 17(2):204-12. DOI: 10.1016/j.stem.2015.07.006. View

4.
Takahashi K, Yamanaka S . Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006; 126(4):663-76. DOI: 10.1016/j.cell.2006.07.024. View

5.
Vierbuchen T, Ostermeier A, Pang Z, Kokubu Y, Sudhof T, Wernig M . Direct conversion of fibroblasts to functional neurons by defined factors. Nature. 2010; 463(7284):1035-41. PMC: 2829121. DOI: 10.1038/nature08797. View