Chemical Characterization and Trypanocidal, Leishmanicidal and Cytotoxicity Potential of Lantana Camara L. (Verbenaceae) Essential Oil

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2016 Feb 16

PMID 26875978

Citations 12

Authors

Luiz Marivando Barros

Antonia Eliene Duarte

Maria Flaviana Bezerra Morais-Braga

Emily Pansera Waczuk

Celeste Vega

Nadghia Figueiredo Leite

Irwin Rose Alencar de Menezes

Henrique Douglas Melo Coutinho

Joao Batista Teixeira Rocha

Jean Paul Kamdem

Affiliations

Soon will be listed here.

Abstract

Drug resistance in the treatment of neglected parasitic diseases, such as leishmaniasis and trypanosomiasis, has led to the search and development of alternative drugs from plant origins. In this context, the essential oil extracted by hydro-distillation from Lantana camara leaves was tested against Leishmania braziliensis and Trypanosoma cruzi. The results demonstrated that L. camara essential oil inhibited T. cruzi and L. braziliensis with IC50 of 201.94 μg/mL and 72.31 μg/mL, respectively. L. camara essential oil was found to be toxic to NCTC929 fibroblasts at 500 μg/mL (IC50 = 301.42 μg/mL). The composition of L. camara essential oil analyzed by gas chromatography-mass spectrometry (GC/MS) revealed large amounts of (E)-caryophyllene (23.75%), biciclogermacrene (15.80%), germacrene D (11.73%), terpinolene (6.1%), and sabinene (5.92%), which might be, at least in part, responsible for its activity. Taken together, our results suggest that L. camara essential oil may be an important source of therapeutic agents for the development of alternative drugs against parasitic diseases.

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