A Prospective Longitudinal Study of Mental Health Symptoms Among Perinatally HIV-Infected and HIV-Exposed but Uninfected Urban Youths

Overview

Journal J Adolesc Health

Publisher Elsevier

Specialty Pediatrics

Date 2016 Feb 14

PMID 26873611

Citations 17

Authors

Massy Mutumba

Jose A Bauermeister

Katherine S Elkington

Amelia Bucek

Curtis Dolezal

Cheng-Shiun Leu

Claude A Mellins

Affiliations

Soon will be listed here.

Abstract

Purpose: Significant gaps persist in our understanding of the etiological factors that shape the progression of mental health symptoms (MHS) among perinatally HIV-infected (PHIV+) and perinatally HIV-exposed but uninfected (PHEU) youths. This study sought to assess the changes in MHS among PHIV+ and PHEU youths as they transition through adolescence and to identify the associated psychosocial factors.

Methods: Data were drawn from a longitudinal study of 166 PHIV+ and 114 PHEU youths (49% male, ages 9-16 years at baseline) in New York City. Individual interviews were administered at baseline and subsequently over a 5-year period. MHS were assessed using the youth version of the Diagnostic Interview Schedule for Children. Predictive growth curve analyses were conducted to assess longitudinal changes in MHS and identify the relevant factors. Level I predictors included: time, major life events, household poverty, caregiver mental health, and neighborhood stressors. Level II predictors included youths' sociodemographic characteristics (e.g., age, gender, HIV status) and baseline future orientation scores.

Results: The changes in youths' MHS followed a quadratic growth curve and were positively associated with the number of major negative life events and neighborhood stressors experienced. Youths' HIV status, household poverty, and caregiver mental health were not significantly associated with youths' MHS.

Conclusions: Findings suggest that irrespective of youths' HIV status, major life events and neighborhood stressors increase MHS among PHIV+ and PHEU youths. There is a need for interventions to reduce the impact of stressors on the mental well-being of PHIV+ and PHEU youths.

Citing Articles

Are Family Factors Differentially Associated with Externalizing Symptoms Among Youth with Perinatally Acquired HIV?.

Drabick D, Jakubovic R, Friedman A, Everett V, Emory G, Gerpe M Child Psychiatry Hum Dev. 2024; .

PMID: 38261149 DOI: 10.1007/s10578-023-01651-5.

Cultural Adaption, Translation, Preliminary Reliability and Validity of Key Psychological and Behavioural Measures for 18 to 25 Year-Olds Living with HIV in Uganda: A Multi-Stage Approach.

Evangeli M, Foster C, Musiime V, Fidler S, Seeley J, Frize G AIDS Behav. 2023; 28(3):924-935.

PMID: 37792229 PMC: 10896775. DOI: 10.1007/s10461-023-04193-y.

Condomless Sex Among HIV-affected AYA in an Era of Undetectable = Untransmittable and Pre-exposure Prophylaxis.

Kluisza L, Attoh-Okine N, Nguyen N, Robbins R, Leu C, Liotta L AIDS Behav. 2023; 27(9):2979-2987.

PMID: 36807245 PMC: 10439969. DOI: 10.1007/s10461-023-04020-4.

HIV and suicide risk across adolescence and young adulthood: an examination of socio-demographic, contextual and psychosocial risk factors for attempted suicide in a longitudinal cohort of ageing adolescents affected by HIV living in the New York....

Kreniske P, Morrison C, Spencer B, Levine A, Liotta L, Fisher P J Int AIDS Soc. 2022; 25 Suppl 4:e25984.

PMID: 36176026 PMC: 9522633. DOI: 10.1002/jia2.25984.

Prevalence and factors associated with common mental disorders in young people living with HIV in sub-Saharan Africa: a systematic review.

Too E, Abubakar A, Nasambu C, Koot H, Cuijpers P, Newton C J Int AIDS Soc. 2021; 24 Suppl 2:e25705.

PMID: 34164931 PMC: 8222842. DOI: 10.1002/jia2.25705.

References

Chan Y, Dennis M, Funk R . Prevalence and comorbidity of major internalizing and externalizing problems among adolescents and adults presenting to substance abuse treatment. J Subst Abuse Treat. 2007; 34(1):14-24. PMC: 2238174. DOI: 10.1016/j.jsat.2006.12.031. View

Kessler R, McGonagle K, Swartz M, Blazer D, Nelson C . Sex and depression in the National Comorbidity Survey. I: Lifetime prevalence, chronicity and recurrence. J Affect Disord. 1993; 29(2-3):85-96. DOI: 10.1016/0165-0327(93)90026-g. View

Bomba M, Nacinovich R, Oggiano S, Cassani M, Baushi L, Bertulli C . Poor health-related quality of life and abnormal psychosocial adjustment in Italian children with perinatal HIV infection receiving highly active antiretroviral treatment. AIDS Care. 2010; 22(7):858-65. DOI: 10.1080/09540120903483018. View

Ewart C, Suchday S . Discovering how urban poverty and violence affect health: development and validation of a Neighborhood Stress Index. Health Psychol. 2002; 21(3):254-62. DOI: 10.1037//0278-6133.21.3.254. View

Yoshikawa H, Aber J, Beardslee W . The effects of poverty on the mental, emotional, and behavioral health of children and youth: implications for prevention. Am Psychol. 2012; 67(4):272-84. DOI: 10.1037/a0028015. View

Gadow K, Angelidou K, Chernoff M, Williams P, Heston J, Hodge J . Longitudinal study of emerging mental health concerns in youth perinatally infected with HIV and peer comparisons. J Dev Behav Pediatr. 2012; 33(6):456-68. PMC: 3520511. DOI: 10.1097/DBP.0b013e31825b8482. View

Mellins C, Brackis-Cott E, Leu C, Elkington K, Dolezal C, Wiznia A . Rates and types of psychiatric disorders in perinatally human immunodeficiency virus-infected youth and seroreverters. J Child Psychol Psychiatry. 2009; 50(9):1131-8. PMC: 2775808. DOI: 10.1111/j.1469-7610.2009.02069.x. View

. Characteristics associated with HIV infection among heterosexuals in urban areas with high AIDS prevalence --- 24 cities, United States, 2006-2007. MMWR Morb Mortal Wkly Rep. 2011; 60(31):1045-9. View

Colman I, Wadsworth M, Croudace T, Jones P . Forty-year psychiatric outcomes following assessment for internalizing disorder in adolescence. Am J Psychiatry. 2007; 164(1):126-33. DOI: 10.1176/ajp.2007.164.1.126. View

10.

Shaffer D, Fisher P, Lucas C, Dulcan M . NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): description, differences from previous versions, and reliability of some common diagnoses. J Am Acad Child Adolesc Psychiatry. 2000; 39(1):28-38. DOI: 10.1097/00004583-200001000-00014. View

11.

Scharko A . DSM psychiatric disorders in the context of pediatric HIV/AIDS. AIDS Care. 2006; 18(5):441-5. DOI: 10.1080/09540120500213487. View

12.

Mellins C, Malee K . Understanding the mental health of youth living with perinatal HIV infection: lessons learned and current challenges. J Int AIDS Soc. 2013; 16:18593. PMC: 3687078. DOI: 10.7448/IAS.16.1.18593. View

13.

Nolen-Hoeksema S, Girgus J . The emergence of gender differences in depression during adolescence. Psychol Bull. 1994; 115(3):424-43. DOI: 10.1037/0033-2909.115.3.424. View

14.

Kang E, Mellins C, Dolezal C, Elkington K, Abrams E . DISADVANTAGED NEIGHBORHOOD INFLUENCES ON DEPRESSION AND ANXIETY IN YOUTH WITH PERINATALLY ACQUIRED HUMAN IMMUNODEFICIENCY VIRUS: HOW LIFE STRESSORS MATTER. J Community Psychol. 2013; 39(8):956-971. PMC: 3587679. DOI: 10.1002/jcop.20483. View

15.

Misdrahi D, Vila G, Funk-Brentano I, Tardieu M, Blanche S, Mouren-Simeoni M . DSM-IV mental disorders and neurological complications in children and adolescents with human immunodeficiency virus type 1 infection (HIV-1). Eur Psychiatry. 2004; 19(3):182-4. DOI: 10.1016/j.eurpsy.2003.06.009. View

16.

Ewart C . Social action theory for a public health psychology. Am Psychol. 1991; 46(9):931-46. DOI: 10.1037//0003-066x.46.9.931. View

17.

Mellins C, Brackis-Cott E, Dolezal C, Leu C, Valentin C, Meyer-Bahlburg H . Mental health of early adolescents from high-risk neighborhoods: the role of maternal HIV and other contextual, self-regulation, and family factors. J Pediatr Psychol. 2008; 33(10):1065-75. PMC: 2734120. DOI: 10.1093/jpepsy/jsn004. View

18.

Malee K, Williams P, Montepiedra G, Nichols S, Sirois P, Storm D . The role of cognitive functioning in medication adherence of children and adolescents with HIV infection. J Pediatr Psychol. 2008; 34(2):164-75. PMC: 2722123. DOI: 10.1093/jpepsy/jsn068. View

19.

Mellins C, Elkington K, Leu C, Karina Santamaria E, Dolezal C, Wiznia A . Prevalence and change in psychiatric disorders among perinatally HIV-infected and HIV-exposed youth. AIDS Care. 2012; 24(8):953-62. PMC: 3416047. DOI: 10.1080/09540121.2012.668174. View

20.

Chernoff M, Nachman S, Williams P, Brouwers P, Heston J, Hodge J . Mental health treatment patterns in perinatally HIV-infected youth and controls. Pediatrics. 2009; 124(2):627-36. PMC: 2764487. DOI: 10.1542/peds.2008-2441. View