Association Between Thyroid Hormone Levels and Insulin Resistance and Body Mass Index

Overview

Journal Pak J Med Sci

Specialty General Medicine

Date 2016 Feb 13

PMID 26870107

Citations 6

Authors

Neval Aksoy

Mustafa Taner Yeler

Nilhan Nurlu Ayan

Ali Ozkeskin

Zeynep Ozkan

N Ozden Serin

Affiliations

Soon will be listed here.

Abstract

Objective: Previous studies have shown an association between thyroid function and insulin resistance and obesity. We compared insulin resistance and body mass index (BMI) in patients with normal TSH levels (2.5-4.2 µIU/mL), patients diagnosed with subclinical hypothyroidism, and healthy control subjects.

Methods: The study included 104 subjects and was conducted at the Taksim Education and Research Hospital. The subjects were divided into three groups according to TSH levels: Group 1 (high-normal), TSH levels were 2.5-4.2 µIU/mL (n=33); Group 2 (subclinical hypothyroidism), TSH levels were 4.2-10 µIU/mL (n=42); and Group 3 (healthy control), TSH levels were 0.27-2.5 µIU/mL (n=29). The fT3 and fT4 levels were within normal limits in all groups. Insulin resistance and BMI were compared among groups. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to estimate insulin resistance.

Results: HOMA-IR and BMI were not significantly different among groups (p>0.05). A significant positive correlation was found between BMI and HOMA-IR in the high-normal TSH (p>0.059) and subclinical hypothyroidism (p>0.05) groups.

Conclusions: HOMA-IR and BMI are important for the assessment of diabetes and cardiovascular diseases. We found no significant difference in HOMA-IR and BMI values among the three TSH reference range groups.

Citing Articles

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The role of thyroid hormone in metabolism and metabolic syndrome.

Teixeira P, Dos Santos P, Pazos-Moura C Ther Adv Endocrinol Metab. 2020; 11:2042018820917869.

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Association between TSH levels within the reference range and adiposity markers at the baseline of the ELSA-Brasil study.

Diniz M, Beleigoli A, Bensenor I, Lotufo P, Goulart A, Barreto S PLoS One. 2020; 15(2):e0228801.

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Abnormal Glucose Metabolism and Insulin Resistance Are Induced via the IRE1α/XBP-1 Pathway in Subclinical Hypothyroidism.

Xu C, Zhou L, Wu K, Li Y, Xu J, Jiang D Front Endocrinol (Lausanne). 2019; 10:303.

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Low total and free triiodothyronine levels are associated with insulin resistance in non-diabetic individuals.

Wang C, Yu T, Shih S, Huang K, Chang T Sci Rep. 2018; 8(1):10685.

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References

Flint E, Cummins S, Sacker A . Associations between active commuting, body fat, and body mass index: population based, cross sectional study in the United Kingdom. BMJ. 2014; 349:g4887. PMC: 4138353. DOI: 10.1136/bmj.g4887. View

Owecki M, Nikisch E, Sowinski J . Hypothyroidism has no impact on insulin sensitivity assessed with HOMA-IR in totally thyroidectomized patients. Acta Clin Belg. 2006; 61(2):69-73. DOI: 10.1179/acb.2006.013. View

Sridevi A, Vivekanand B, Giridhar G, Mythili A, Subrahmanyan K . Insulin resistance and lipid alterations in subclinical hypothyroidism. Indian J Endocrinol Metab. 2013; 16(Suppl 2):S345-6. PMC: 3603070. DOI: 10.4103/2230-8210.104085. View

Volzke H, Ludemann J, Robinson D, Spieker K, Schwahn C, Kramer A . The prevalence of undiagnosed thyroid disorders in a previously iodine-deficient area. Thyroid. 2003; 13(8):803-10. DOI: 10.1089/105072503768499680. View

Dimitriadis G, Mitrou P, Lambadiari V, Boutati E, Maratou E, Panagiotakos D . Insulin action in adipose tissue and muscle in hypothyroidism. J Clin Endocrinol Metab. 2006; 91(12):4930-7. DOI: 10.1210/jc.2006-0478. View

Singh B, Goswami B, Mallika V . Association between insulin resistance and hypothyroidism in females attending a tertiary care hospital. Indian J Clin Biochem. 2012; 25(2):141-5. PMC: 3453097. DOI: 10.1007/s12291-010-0026-x. View

Ren R, Jiang X, Zhang X, Guan Q, Yu C, Li Y . Association between thyroid hormones and body fat in euthyroid subjects. Clin Endocrinol (Oxf). 2013; 80(4):585-90. DOI: 10.1111/cen.12311. View

Negami M, Takahashi E, Otsuka H, Moriyama K . Prediction of homeostasis model assessment of insulin resistance in Japanese subjects. Tokai J Exp Clin Med. 2012; 37(4):102-6. View

Vyakaranam S, Vanaparthy S, Nori S, Palarapu S, Bhongir A . Study of Insulin Resistance in Subclinical Hypothyroidism. Int J Health Sci Res. 2015; 4(9):147-153. PMC: 4286301. View

10.

Bougle D, Morello R, Brouard J . Thyroid function and metabolic risk factors in obese youth. Changes during follow-up: a preventive mechanism?. Exp Clin Endocrinol Diabetes. 2014; 122(9):548-52. DOI: 10.1055/s-0034-1377046. View

11.

Kong W, Sheikh M, Lumb P, Naoumova R, Freedman D, Crook M . A 6-month randomized trial of thyroxine treatment in women with mild subclinical hypothyroidism. Am J Med. 2002; 112(5):348-54. DOI: 10.1016/s0002-9343(02)01022-7. View

12.

Maratou E, Hadjidakis D, Kollias A, Tsegka K, Peppa M, Alevizaki M . Studies of insulin resistance in patients with clinical and subclinical hypothyroidism. Eur J Endocrinol. 2009; 160(5):785-90. DOI: 10.1530/EJE-08-0797. View

13.

Lambadiari V, Mitrou P, Maratou E, Raptis A, Tountas N, Raptis S . Thyroid hormones are positively associated with insulin resistance early in the development of type 2 diabetes. Endocrine. 2010; 39(1):28-32. DOI: 10.1007/s12020-010-9408-3. View

14.

Tseng F, Lin W, Lin C, Lee L, Li T, Sung P . Subclinical hypothyroidism is associated with increased risk for all-cause and cardiovascular mortality in adults. J Am Coll Cardiol. 2012; 60(8):730-7. DOI: 10.1016/j.jacc.2012.03.047. View

15.

Wartofsky L, Dickey R . The evidence for a narrower thyrotropin reference range is compelling. J Clin Endocrinol Metab. 2005; 90(9):5483-8. DOI: 10.1210/jc.2005-0455. View

16.

Zulewski H, Muller B, Exer P, Miserez A, Staub J . Estimation of tissue hypothyroidism by a new clinical score: evaluation of patients with various grades of hypothyroidism and controls. J Clin Endocrinol Metab. 1997; 82(3):771-6. DOI: 10.1210/jcem.82.3.3810. View

17.

Surks M, Ortiz E, Daniels G, Sawin C, Col N, Cobin R . Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA. 2004; 291(2):228-38. DOI: 10.1001/jama.291.2.228. View

18.

Garduno-Garcia J, Romero E, Loe Ochoa A, Romero-Figueroa S, Huitron Bravo G, Torres Garcia R . Thyroid function is associated with insulin resistance markers in healthy adolescents with risk factors to develop diabetes. Diabetol Metab Syndr. 2015; 7:16. PMC: 4361132. DOI: 10.1186/s13098-015-0011-x. View

19.

Fatourechi V . Subclinical hypothyroidism: an update for primary care physicians. Mayo Clin Proc. 2009; 84(1):65-71. PMC: 2664572. DOI: 10.4065/84.1.65. View

20.

Brabant G, Beck-Peccoz P, Jarzab B, Laurberg P, Orgiazzi J, Szabolcs I . Is there a need to redefine the upper normal limit of TSH?. Eur J Endocrinol. 2006; 154(5):633-7. DOI: 10.1530/eje.1.02136. View