Oct-4 is Associated with Gastric Cancer Progression and Prognosis

Overview

Journal Onco Targets Ther

Publisher Dove Medical Press

Specialty Oncology

Date 2016 Feb 13

PMID 26869797

Citations 10

Authors

Wen-Li Jiang

Peng-Fei Zhang

Guo-Feng Li

Jian-Hua Dong

Xue-Song Wang

Yuan-Yu Wang

Affiliations

Soon will be listed here.

Abstract

Aim: To investigate the clinical significance of Oct-4 in the development and progression of gastric cancer.

Methods: Immunohistochemistry was used to analyze Oct-4 expression in 412 gastric cancer cases. Oct-4 protein levels were upregulated in gastric cancer tissues compared with adjacent noncancerous tissues.

Results: Positive expression of Oct-4 correlated with age, depth of invasion, Lauren classification, lymph node metastasis, distant metastasis, and TNM stage. In stages I, II, and III, the 5-year survival rate of patients with high expression of Oct-4 was significantly lower than that in patients with low expression of Oct-4. In stage IV, Oct-4 expression did not correlate with the 5-year survival rate. Furthermore, multivariate analysis suggested that the depth of invasion, lymph node metastasis, distant metastasis, TNM stage, and upregulation of Oct-4 were independent prognostic factors of gastric cancer.

Conclusion: Oct-4 protein is a useful marker in predicting tumor progression and prognosis.

Citing Articles

Oct4 promoted proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in colon cancer cells by activating the SCF/c-Kit signaling pathway.

Bu X, Liu Y, Wang L, Yan Z, Xin G, Su W Cell Cycle. 2022; 22(3):291-302.

PMID: 36258646 PMC: 9851249. DOI: 10.1080/15384101.2022.2112486.

OCT4-mediated transcription confers oncogenic advantage for a subset of gastric tumors with poor clinical outcome.

Pandian J, Panneerpandian P, Sekar B, Selvarasu K, Ganesan K Funct Integr Genomics. 2022; 22(6):1345-1360.

PMID: 35987846 DOI: 10.1007/s10142-022-00894-0.

Stem Cell Biomarkers and Tumorigenesis in Gastric Cancer.

Wuputra K, Ku C, Pan J, Liu C, Liu Y, Saito S J Pers Med. 2022; 12(6).

PMID: 35743714 PMC: 9224738. DOI: 10.3390/jpm12060929.

Resveratrol Analog 4-Bromo-Resveratrol Inhibits Gastric Cancer Stemness through the SIRT3-c-Jun N-Terminal Kinase Signaling Pathway.

Tai Y, Ma Y, Chen C, Tsai H, Tsai C, Wu M Curr Issues Mol Biol. 2022; 44(1):63-72.

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DEK modulates both expression and alternative splicing of cancer‑related genes.

Liu B, Sun Y, Zhang Y, Xing Y, Suo J Oncol Rep. 2022; 47(6).

PMID: 35475534 PMC: 9073418. DOI: 10.3892/or.2022.8322.

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