Inositol Polyphosphate Multikinase (IPMK) in Transcriptional Regulation and Nuclear Inositide Metabolism

Overview

Journal Biochem Soc Trans

Specialty Biochemistry

Date 2016 Feb 11

PMID 26862216

Citations 17

Authors

M Merced Malabanan

Raymond D Blind

Affiliations

Soon will be listed here.

Abstract

Inositol polyphosphate multikinase (IPMK, ipk2, Arg(82), ArgRIII) is an inositide kinase with unusually flexible substrate specificity and the capacity to partake in many functional protein-protein interactions (PPIs). By merging these two activities, IPMK is able to execute gene regulatory functions that are very unique and only now beginning to be recognized. In this short review, we present a brief history of IPMK, describe the structural biology of the enzyme and highlight a few recent discoveries that have shed more light on the role IPMK plays in inositide metabolism, nuclear signalling and transcriptional regulation.

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References

Batty I, Nahorski S, Irvine R . Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices. Biochem J. 1985; 232(1):211-5. PMC: 1152860. DOI: 10.1042/bj2320211. View

Li A, Piluso L, Cai X, Wei G, Sellers W, Liu X . Mechanistic insights into maintenance of high p53 acetylation by PTEN. Mol Cell. 2006; 23(4):575-87. DOI: 10.1016/j.molcel.2006.06.028. View

York J . Regulation of nuclear processes by inositol polyphosphates. Biochim Biophys Acta. 2006; 1761(5-6):552-9. DOI: 10.1016/j.bbalip.2006.04.014. View

Irvine R, Letcher A, Lander D, Downes C . Inositol trisphosphates in carbachol-stimulated rat parotid glands. Biochem J. 1984; 223(1):237-43. PMC: 1144285. DOI: 10.1042/bj2230237. View

Kim S, Kim S, Maag D, Maxwell M, Resnick A, Juluri K . Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase. Cell Metab. 2011; 13(2):215-21. PMC: 3042716. DOI: 10.1016/j.cmet.2011.01.007. View

Sablin E, Blind R, Krylova I, Ingraham J, Cai F, Williams J . Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands. Mol Endocrinol. 2008; 23(1):25-34. PMC: 2646595. DOI: 10.1210/me.2007-0508. View

Estevez F, Pulford D, Stark M, Carter A, Downes C . Inositol trisphosphate metabolism in Saccharomyces cerevisiae: identification, purification and properties of inositol 1,4,5-trisphosphate 6-kinase. Biochem J. 1994; 302 ( Pt 3):709-16. PMC: 1137289. DOI: 10.1042/bj3020709. View

Blind R, Suzawa M, Ingraham H . Direct modification and activation of a nuclear receptor-PIP₂ complex by the inositol lipid kinase IPMK. Sci Signal. 2012; 5(229):ra44. PMC: 3395721. DOI: 10.1126/scisignal.2003111. View

Xu R, Snyder S . Gene transcription by p53 requires inositol polyphosphate multikinase as a co-activator. Cell Cycle. 2013; 12(12):1819-20. PMC: 3735690. DOI: 10.4161/cc.25119. View

10.

Sei Y, Zhao X, Forbes J, Szymczak S, Li Q, Trivedi A . A Hereditary Form of Small Intestinal Carcinoid Associated With a Germline Mutation in Inositol Polyphosphate Multikinase. Gastroenterology. 2015; 149(1):67-78. PMC: 4858647. DOI: 10.1053/j.gastro.2015.04.008. View

11.

Kim S, Snyder S . Nutrient amino acids signal to mTOR via inositol polyphosphate multikinase. Cell Cycle. 2011; 10(11):1708-10. DOI: 10.4161/cc.10.11.15559. View

12.

Ongusaha P, Hughes P, Davey J, Michell R . Inositol hexakisphosphate in Schizosaccharomyces pombe: synthesis from Ins(1,4,5)P3 and osmotic regulation. Biochem J. 1998; 335 ( Pt 3):671-9. PMC: 1219831. DOI: 10.1042/bj3350671. View

13.

Wickramasinghe V, Savill J, Chavali S, Jonsdottir A, Rajendra E, Gruner T . Human inositol polyphosphate multikinase regulates transcript-selective nuclear mRNA export to preserve genome integrity. Mol Cell. 2013; 51(6):737-50. DOI: 10.1016/j.molcel.2013.08.031. View

14.

Streb H, Irvine R, Berridge M, Schulz I . Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature. 1983; 306(5938):67-9. DOI: 10.1038/306067a0. View

15.

Takazawa K, Perret J, Dumont J, Erneux C . Molecular cloning and expression of a human brain inositol 1,4,5-trisphosphate 3-kinase. Biochem Biophys Res Commun. 1991; 174(2):529-35. DOI: 10.1016/0006-291x(91)91449-m. View

16.

Dailey M, Kim S . Inositol polyphosphate multikinase: an emerging player for the central action of AMP-activated protein kinase. Biochem Biophys Res Commun. 2012; 421(1):1-3. PMC: 3341469. DOI: 10.1016/j.bbrc.2012.04.010. View

17.

Saiardi A, Nagata E, Luo H, Sawa A, Luo X, Snowman A . Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate. Proc Natl Acad Sci U S A. 2001; 98(5):2306-11. PMC: 30134. DOI: 10.1073/pnas.041614598. View

18.

Dubois E, Messenguy F . Pleiotropic function of ArgRIIIp (Arg82p), one of the regulators of arginine metabolism in Saccharomyces cerevisiae. Role in expression of cell-type-specific genes. Mol Gen Genet. 1994; 243(3):315-24. DOI: 10.1007/BF00301067. View

19.

Resnick A, Saiardi A . Inositol polyphosphate multikinase: metabolic architect of nuclear inositides. Front Biosci. 2007; 13:856-66. DOI: 10.2741/2726. View

20.

Kim E, Tyagi R, Lee J, Park J, Kim Y, Beon J . Inositol polyphosphate multikinase is a coactivator for serum response factor-dependent induction of immediate early genes. Proc Natl Acad Sci U S A. 2013; 110(49):19938-43. PMC: 3856792. DOI: 10.1073/pnas.1320171110. View