Argonaute and Argonaute-Bound Small RNAs in Stem Cells

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2016 Feb 11

PMID 26861290

Citations 3

Authors

Lihong Zhai

Lin Wang

Feng Teng

Lanting Zhou

Wenjing Zhang

Juan Xiao

Ying Liu

Wenbin Deng

Affiliations

Soon will be listed here.

Abstract

Small RNAs are essential for a variety of cellular functions. Argonaute (AGO) proteins are associated with all of the different classes of small RNAs, and are indispensable in small RNA-mediated regulatory pathways. AGO proteins have been identified in various types of stem cells in diverse species from plants and animals. This review article highlights recent progress on how AGO proteins and AGO-bound small RNAs regulate the self-renewal and differentiation of distinct stem cell types, including pluripotent, germline, somatic, and cancer stem cells.

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References

Chandra Shekar P, Naim A, Sarathi D, Kumar S . Argonaute-2-null embryonic stem cells are retarded in self-renewal and differentiation. J Biosci. 2011; 36(4):649-57. DOI: 10.1007/s12038-011-9094-1. View

Takeda A, Iwasaki S, Watanabe T, Utsumi M, Watanabe Y . The mechanism selecting the guide strand from small RNA duplexes is different among argonaute proteins. Plant Cell Physiol. 2008; 49(4):493-500. DOI: 10.1093/pcp/pcn043. View

Jin Z, Flynt A, Lai E . Drosophila piwi mutants exhibit germline stem cell tumors that are sustained by elevated Dpp signaling. Curr Biol. 2013; 23(15):1442-8. PMC: 3740069. DOI: 10.1016/j.cub.2013.06.021. View

Manavella P, Weigel D, Wu L . Argonaute10 as a miRNA locker. Cell. 2011; 145(2):173-4. DOI: 10.1016/j.cell.2011.03.045. View

Pfaff J, Hennig J, Herzog F, Aebersold R, Sattler M, Niessing D . Structural features of Argonaute-GW182 protein interactions. Proc Natl Acad Sci U S A. 2013; 110(40):E3770-9. PMC: 3791723. DOI: 10.1073/pnas.1308510110. View

Nakanishi K, Weinberg D, Bartel D, Patel D . Structure of yeast Argonaute with guide RNA. Nature. 2012; 486(7403):368-74. PMC: 3853139. DOI: 10.1038/nature11211. View

Nishimura A, Ito M, Kamiya N, Sato Y, Matsuoka M . OsPNH1 regulates leaf development and maintenance of the shoot apical meristem in rice. Plant J. 2002; 30(2):189-201. DOI: 10.1046/j.1365-313x.2002.01279.x. View

Nonomura K, Morohoshi A, Nakano M, Eiguchi M, Miyao A, Hirochika H . A germ cell specific gene of the ARGONAUTE family is essential for the progression of premeiotic mitosis and meiosis during sporogenesis in rice. Plant Cell. 2007; 19(8):2583-94. PMC: 2002623. DOI: 10.1105/tpc.107.053199. View

Carmell M, Xuan Z, Zhang M, Hannon G . The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes Dev. 2002; 16(21):2733-42. DOI: 10.1101/gad.1026102. View

10.

Liu W, Gao Q, Chen K, Xue X, Li M, Chen Q . Hiwi facilitates chemoresistance as a cancer stem cell marker in cervical cancer. Oncol Rep. 2014; 32(5):1853-60. DOI: 10.3892/or.2014.3401. View

11.

Matzke M, Mosher R . RNA-directed DNA methylation: an epigenetic pathway of increasing complexity. Nat Rev Genet. 2014; 15(6):394-408. DOI: 10.1038/nrg3683. View

12.

Mallory A, Hinze A, Tucker M, Bouche N, Gasciolli V, Elmayan T . Redundant and specific roles of the ARGONAUTE proteins AGO1 and ZLL in development and small RNA-directed gene silencing. PLoS Genet. 2009; 5(9):e1000646. PMC: 2730571. DOI: 10.1371/journal.pgen.1000646. View

13.

Klenov M, Sokolova O, Yakushev E, Stolyarenko A, Mikhaleva E, Lavrov S . Separation of stem cell maintenance and transposon silencing functions of Piwi protein. Proc Natl Acad Sci U S A. 2011; 108(46):18760-5. PMC: 3219103. DOI: 10.1073/pnas.1106676108. View

14.

Mallory A, Vaucheret H . Form, function, and regulation of ARGONAUTE proteins. Plant Cell. 2010; 22(12):3879-89. PMC: 3027166. DOI: 10.1105/tpc.110.080671. View

15.

Brennecke J, Aravin A, Stark A, Dus M, Kellis M, Sachidanandam R . Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell. 2007; 128(6):1089-103. DOI: 10.1016/j.cell.2007.01.043. View

16.

Eun C, Lorkovic Z, Naumann U, Long Q, Havecker E, Simon S . AGO6 functions in RNA-mediated transcriptional gene silencing in shoot and root meristems in Arabidopsis thaliana. PLoS One. 2011; 6(10):e25730. PMC: 3187791. DOI: 10.1371/journal.pone.0025730. View

17.

Dzianott A, Sztuba-Solinska J, Bujarski J . Mutations in the antiviral RNAi defense pathway modify Brome mosaic virus RNA recombinant profiles. Mol Plant Microbe Interact. 2011; 25(1):97-106. DOI: 10.1094/MPMI-05-11-0137. View

18.

Aravin A, Sachidanandam R, Bourchis D, Schaefer C, Pezic D, Fejes Toth K . A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol Cell. 2008; 31(6):785-99. PMC: 2730041. DOI: 10.1016/j.molcel.2008.09.003. View

19.

Lynn K, Fernandez A, Aida M, Sedbrook J, Tasaka M, Masson P . The PINHEAD/ZWILLE gene acts pleiotropically in Arabidopsis development and has overlapping functions with the ARGONAUTE1 gene. Development. 1999; 126(3):469-81. DOI: 10.1242/dev.126.3.469. View

20.

Wu Q, Ma Q, Shehadeh L, Wilson A, Xia L, Yu H . Expression of the Argonaute protein PiwiL2 and piRNAs in adult mouse mesenchymal stem cells. Biochem Biophys Res Commun. 2010; 396(4):915-20. PMC: 3151571. DOI: 10.1016/j.bbrc.2010.05.022. View