Filament Assemblies in Foreign Nucleic Acid Sensors

Overview

Journal Curr Opin Struct Biol

Date 2016 Feb 10

PMID 26859869

Citations 38

Authors

Jungsan Sohn

Sun Hur

Affiliations

Soon will be listed here.

Abstract

Helical filamentous assembly is ubiquitous in biology, but was only recently realized to be broadly employed in the innate immune system of vertebrates. Accumulating evidence suggests that the filamentous assemblies and helical oligomerization play important roles in detection of foreign nucleic acids and activation of the signaling pathways to produce antiviral and inflammatory mediators. In this review, we focus on the helical assemblies observed in the signaling pathways of RIG-I-like receptors (RLRs) and AIM2-like receptors (ALRs). We describe ligand-dependent oligomerization of receptor, receptor-dependent oligomerization of signaling adaptor molecules, and their functional implications and regulations.

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