Potential Applications of Using 68Ga-Evans Blue PET/CT in the Evaluation of Lymphatic Disorder: Preliminary Observations

Overview

Journal Clin Nucl Med

Specialty Nuclear Medicine

Date 2016 Feb 10

PMID 26859218

Citations 9

Authors

Wei Zhang

Peilin Wu

Fang Li

Guansheng Tong

Xiaoyuan Chen

Zhaohui Zhu

Affiliations

Soon will be listed here.

Abstract

Purpose: Potentials of 68Ga-NEB as a PET tracer in the evaluation of a variety of lymphatic drainage disorders were analyzed.

Methods: 68Ga-NEB was injected subcutaneously, and the PET/CT images were acquired in 13 patients with different suspected lymphatic drainage abnormality. The 68Ga-NEB PET/CT findings were compared with Tc-SC lymphoscintigraphy.

Results: 68Ga-NEB activity could be clearly observed in the lymphatic route on the PET/CT images from all the patients. In 5 (38.5%) of 13 patients tested, 68Ga-NEB PET/CT provided more information than the Tc-SC lymphoscintigraphy.

Conclusions: 68Ga-NEB PET/CT can be used as an alternative of Tc-SC lymphoscintigraphy in the evaluation of lymphatic disorders, which enables fast results and might be more accurate than the conventional Tc-SC lymphoscintigraphy.

Citing Articles

68Ga-NEB PET/CT can be a new method for diagnosing chylous fistula: Case reports of a rare complication after breast cancer surgery.

Peng L, Zhao J, Mao F, Sun Q Medicine (Baltimore). 2020; 99(29):e21201.

PMID: 32702884 PMC: 7373633. DOI: 10.1097/MD.0000000000021201.

Positron emission tomography/computed tomography findings of multiple cystic lymphangiomas in an adult: A case report.

Sun M, Shen J World J Clin Cases. 2020; 8(10):1973-1978.

PMID: 32518789 PMC: 7262707. DOI: 10.12998/wjcc.v8.i10.1973.

Hemolymphangioma involving bones and bladder detected on 68Ga-NEB PET/CT: A rare case report.

Hou G, Jiang Y, Jian S, Niu Y, Cheng W Medicine (Baltimore). 2019; 98(15):e15213.

PMID: 30985720 PMC: 6485884. DOI: 10.1097/MD.0000000000015213.

68Ga-NOTA-Evans Blue TOF PET/MR Lymphoscintigraphy Evaluation of the Severity of Lower Limb Lymphedema.

Hou G, Hou B, Jiang Y, Zhu Z, Long X, Chen X Clin Nucl Med. 2019; 44(6):439-445.

PMID: 30985414 PMC: 6502703. DOI: 10.1097/RLU.0000000000002584.

Evans Blue Dye: A Revisit of Its Applications in Biomedicine.

Yao L, Xue X, Yu P, Ni Y, Chen F Contrast Media Mol Imaging. 2018; 2018:7628037.

PMID: 29849513 PMC: 5937594. DOI: 10.1155/2018/7628037.

References

Tsopelas C, Sutton R . Why certain dyes are useful for localizing the sentinel lymph node. J Nucl Med. 2002; 43(10):1377-82. View

Warren A, Brorson H, Borud L, Slavin S . Lymphedema: a comprehensive review. Ann Plast Surg. 2007; 59(4):464-72. DOI: 10.1097/01.sap.0000257149.42922.7e. View

Kim D, Kim M, Kim C . Lymphoscintigraphy revealed chyloperitoneum after gastrectomy for gastric cancer. Clin Nucl Med. 2014; 40(1):41-4. DOI: 10.1097/RLU.0000000000000609. View

Tsopelas C, Bellon M, Bevington E, Kollias J, Shibli S, Chatterton B . Lymphatic mapping with 99mTc-Evans Blue dye in sheep. Ann Nucl Med. 2008; 22(9):777-85. DOI: 10.1007/s12149-008-0171-y. View

Pui M, YUEH T . Lymphoscintigraphy in chyluria, chyloperitoneum and chylothorax. J Nucl Med. 1998; 39(7):1292-6. View

Atkinson C, Banks K . Imaging Idiopathic Chylopericardium With 99mTc-SC Lymphoscintigraphy and SPECT/CT. Clin Nucl Med. 2015; 40(11):e508-10. DOI: 10.1097/RLU.0000000000000944. View

Yang J, Codreanu I, Zhuang H . Minimal lymphatic leakage in an infant with chylothorax detected by lymphoscintigraphy SPECT/CT. Pediatrics. 2014; 134(2):e606-10. DOI: 10.1542/peds.2013-2689. View

Witte M, Williams W . Chylothorax and chyloperitoneum. N Engl J Med. 2006; 354(8):879. DOI: 10.1056/NEJMc052422. View

Muskhelishvili L, Thompson P, Kusewitt D, Wang C, Kadlubar F . In situ hybridization and immunohistochemical analysis of cytochrome P450 1B1 expression in human normal tissues. J Histochem Cytochem. 2001; 49(2):229-36. DOI: 10.1177/002215540104900210. View

10.

Prevot N, Tiffet O, Avet Jr J, Quak E, Decousus M, Dubois F . Lymphoscintigraphy and SPECT/CT using 99mTc filtered sulphur colloid in chylothorax. Eur J Nucl Med Mol Imaging. 2011; 38(9):1746. DOI: 10.1007/s00259-011-1793-1. View

11.

Weiss M, Schwarz F, Wallmichrath J, Baumeister R, Frick A, Bartenstein P . Chylothorax and chylous ascites. Clinical utility of planar scintigraphy and tomographic imaging with SPECT/CT. Nuklearmedizin. 2015; 54(5):231-40. DOI: 10.3413/Nukmed-0723-15-02. View

12.

Oh J, Yoon H, Chung Y . Lymphoscintigraphic demonstration of chyle leak after kidney transplantation and gamma camera detection of radioactivity in chylous aspirate. Clin Nucl Med. 2014; 39(8):760-1. DOI: 10.1097/RLU.0000000000000482. View

13.

Green M, Farshid G, Kollias J, Chatterton B, Tsopelas C . The tissue distribution of Evans blue dye in a sheep model of sentinel node biopsy. Nucl Med Commun. 2006; 27(9):695-700. DOI: 10.1097/01.mnm.0000230068.08576.24. View

14.

Gupta R, Kitaichi M, Inoue Y, Kotloff R, McCormack F . Lymphatic manifestations of lymphangioleiomyomatosis. Lymphology. 2014; 47(3):106-17. View

15.

Han D, Cheng M, Yen R, Tzen K, Wu Y . Postoperative lymphocele demonstrated by lymphoscintigraphy SPECT/CT. Clin Nucl Med. 2012; 37(4):374-6. DOI: 10.1097/RLU.0b013e31823eac5e. View

16.

Tsopelas C, Bevington E, Kollias J, Shibli S, Farshid G, Coventry B . 99mTc-Evans blue dye for mapping contiguous lymph node sequences and discriminating the sentinel lymph node in an ovine model. Ann Surg Oncol. 2006; 13(5):692-700. DOI: 10.1245/ASO.2006.04.020. View

17.

Hung J, Wiseman G, Wahner H, Mullan B, Taggart T, Dunn W . Filtered technetium-99m-sulfur colloid evaluated for lymphoscintigraphy. J Nucl Med. 1995; 36(10):1895-901. View

18.

Baulieu F, Bourgeois P, Maruani A, Belgrado J, Tauveron V, Lorette G . Contributions of SPECT/CT imaging to the lymphoscintigraphic investigations of the lower limb lymphedema. Lymphology. 2014; 46(3):106-19. View

19.

Steagall W, Taveira-DaSilva A, Moss J . Clinical and molecular insights into lymphangioleiomyomatosis. Sarcoidosis Vasc Diffuse Lung Dis. 2006; 22 Suppl 1:S49-66. View

20.

Kazemzadeh G, Sadeghi R, Ebrahimi E, Ghodsi Rad M . A successful experience in managing a chylous reflux: importance of lymphoscintigraphy. Clin Nucl Med. 2014; 39(5):485-7. DOI: 10.1097/RLU.0000000000000418. View