Novel Investigations of Flavonoids As Chemopreventive Agents for Hepatocellular Carcinoma

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2016 Feb 10

PMID 26858957

Citations 43

Authors

Chen-Yi Liao

Ching-Chang Lee

Chi-Chang Tsai

Chao-Wen Hsueh

Chih-Chiang Wang

I-Hung Chen

Ming-Kai Tsai

Mei-Yu Liu

An-Tie Hsieh

Kuan-Jen Su

Hau-Ming Wu

Shih-Chung Huang

Yi-Chen Wang

Chien-Yao Wang

Shu-Fang Huang

Yen-Cheng Yeh

Ren-Jy Ben

Shang-Tao Chien

Chin-Wen Hsu

Wu-Hsien Kuo

Affiliations

Soon will be listed here.

Abstract

We would like to highlight the application of natural products to hepatocellular carcinoma (HCC). We will focus on the natural products known as flavonoids, which target this disease at different stages of hepatocarcinogenesis. In spite of the use of chemotherapy and radiotherapy in treating HCC, patients with HCC still face poor prognosis because of the nature of multidrug resistance and toxicity derived from chemotherapy and radiotherapy. Flavonoids can be found in many vegetables, fruits, and herbal medicines that exert their different anticancer effects via different intracellular signaling pathways and serve as antioxidants. In this review, we will discuss seven common flavonoids that exert different biological effects against HCC via different pathways.

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