A Review of Autologous Islet Transplantation

Overview

Journal Cell Med

Publisher Sage Publications

Date 2016 Feb 10

PMID 26858866

Citations 4

Authors

Michihiro Maruyama

Takashi Kenmochi

Naotake Akutsu

Kazunori Otsuki

Taihei Ito

Ikuko Matsumoto

Takehide Asano

Affiliations

Soon will be listed here.

Abstract

Autologous islet transplantation after total or semitotal pancreatectomy aims to preserve insulin secretory function and prevent the onset of diabetes. The major indication for pancreatectomy is chronic pancreatitis with severe abdominal pain, a benign pancreatic tumor, and trauma. The metabolic outcome of autologous islet transplantation is better than that of allogeneic transplantation and depends on the number of transplanted islets. Achieving islet isolation from a fibrous or damaged pancreas is one of the biggest challenges of autologous islet transplantation; a major complication is portal vein thrombosis after crude islet infusion. However, the incidence of portal vein thrombosis has decreased as islet preparation techniques have improved over time.

Citing Articles

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Portal Vein Thrombosis After Total Pancreatectomy and Islet Autotransplant: Prophylaxis and Graft Impact.

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