Clostridium Butyricum in Combination with Specific Immunotherapy Converts Antigen-specific B Cells to Regulatory B Cells in Asthmatic Patients

Overview

Journal Sci Rep

Specialty Science

Date 2016 Feb 10

PMID 26857726

Citations 17

Authors

Hong-Ying Liao

Li Tao

Jian Zhao

Jie Qin

Gu-Cheng Zeng

Song-Wang Cai

Yun Li

Jian Zhang

Hui-Guo Chen

Affiliations

Soon will be listed here.

Abstract

The effect of antigen specific immunotherapy (SIT) on asthma is supposed to be improved. Published data indicate that administration of probiotics alleviates allergic diseases. B cells play important roles in the pathogenesis of allergic diseases. This study aims to modulate antigen specific B cell property by the administration of Clostridium butyrate (CB) in combination with SIT. The results showed that after a 3-month treatment, the total asthma clinical score and serum specific IgE were improved in the patients treated with SIT, which was further improved in those treated with both SIT and CB, but not in those treated with CB alone. Treatment with SIT and CB increased p300 and STAT3 activation, up regulated the IL-10 gene transcription and increased the frequency of peripheral antigen specific B cells. In conclusion, administration with SIT in combination with CB converts Der p 1 specific B cells to regulatory B cells in asthma patients allergic to Der p 1. The data suggest a potential therapeutic remedy in the treatment of allergic diseases.

Citing Articles

Isolation and Characterization of Probiotic Bacteria from Traditional Foods.

Davoodbasha M, Mani A, Arunachalam K, Jagadeesan A, Kamli M, Kim J Appl Biochem Biotechnol. 2024; .

PMID: 39714558 DOI: 10.1007/s12010-024-05125-9.

Supplementation of Parachlorella sp. in feed promote the gut microbiome colonization and fecal IgA response of broiler in both early and late period.

Ji W, Kim T, Lee C, Kim Z, Jung J, Ban B Poult Sci. 2024; 104(1):104572.

PMID: 39631282 PMC: 11665406. DOI: 10.1016/j.psj.2024.104572.

Beyond allergic progression: From molecules to microbes as barrier modulators in the gut-lung axis functionality.

Parron-Ballesteros J, Gordo R, Lopez-Rodriguez J, Olmo N, Villalba M, Batanero E Front Allergy. 2023; 4:1093800.

PMID: 36793545 PMC: 9923236. DOI: 10.3389/falgy.2023.1093800.

Aerosol Inhalation of Heat-Killed CGMCC0313-1 Alleviates Allergic Airway Inflammation in Mice.

Li L, Sun Q, Xiao H, Zhang Q, Xu S, Lai L J Immunol Res. 2022; 2022:8447603.

PMID: 36033385 PMC: 9410851. DOI: 10.1155/2022/8447603.

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition).

Cossarizza A, Chang H, Radbruch A, Abrignani S, Addo R, Akdis M Eur J Immunol. 2021; 51(12):2708-3145.

PMID: 34910301 PMC: 11115438. DOI: 10.1002/eji.202170126.

References

van der Valk J, de Jong N, Gerth van Wijk R . Review on immunotherapy in airway allergen sensitised patients. Neth J Med. 2015; 73(6):263-9. View

Vitaliti G, Pavone P, Guglielmo F, Spataro G, Falsaperla R . The immunomodulatory effect of probiotics beyond atopy: an update. J Asthma. 2013; 51(3):320-32. DOI: 10.3109/02770903.2013.862259. View

Geng X, Yang G, Li M, Song J, Liu Z, Qiu S . Insulin-like growth factor-2 enhances functions of antigen (Ag)-specific regulatory B cells. J Biol Chem. 2014; 289(25):17941-50. PMC: 4067224. DOI: 10.1074/jbc.M113.515262. View

Hardy H, Harris J, Lyon E, Beal J, Foey A . Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology. Nutrients. 2013; 5(6):1869-912. PMC: 3725482. DOI: 10.3390/nu5061869. View

Soyka M, Veen W, Holzmann D, Akdis M, Akdis C . Scientific foundations of allergen-specific immunotherapy for allergic disease. Chest. 2014; 146(5):1347-1357. DOI: 10.1378/chest.14-0049. View

Toh Z, Anzela A, Tang M, Licciardi P . Probiotic therapy as a novel approach for allergic disease. Front Pharmacol. 2012; 3:171. PMC: 3448073. DOI: 10.3389/fphar.2012.00171. View

Ni J, Shen Y, Wang Z, Shao D, Liu J, Kong Y . P300-dependent STAT3 acetylation is necessary for angiotensin II-induced pro-fibrotic responses in renal tubular epithelial cells. Acta Pharmacol Sin. 2014; 35(9):1157-66. PMC: 4155527. DOI: 10.1038/aps.2014.54. View

Andersson C, Tufvesson E, Diamant Z, Bjermer L . Revisiting the role of the mast cell in asthma. Curr Opin Pulm Med. 2015; 22(1):10-7. DOI: 10.1097/MCP.0000000000000228. View

Noh G, Lee J . Oral tolerance induction for human food allergy. Inflamm Allergy Drug Targets. 2012; 11(2):131-42. DOI: 10.2174/187152812800392869. View

10.

Tedder T . B10 cells: a functionally defined regulatory B cell subset. J Immunol. 2015; 194(4):1395-401. DOI: 10.4049/jimmunol.1401329. View

11.

Akdis C, Akdis M . Advances in allergen immunotherapy: aiming for complete tolerance to allergens. Sci Transl Med. 2015; 7(280):280ps6. DOI: 10.1126/scitranslmed.aaa7390. View

12.

Uphoff E, Cabieses B, Pinart M, Valdes M, Anto J, Wright J . A systematic review of socioeconomic position in relation to asthma and allergic diseases. Eur Respir J. 2014; 46(2):364-74. DOI: 10.1183/09031936.00114514. View

13.

Patten D, Laws A . Lactobacillus-produced exopolysaccharides and their potential health benefits: a review. Benef Microbes. 2015; 6(4):457-71. DOI: 10.3920/BM2014.0117. View

14.

Kaur I, Chopra K, Saini A . Probiotics: potential pharmaceutical applications. Eur J Pharm Sci. 2002; 15(1):1-9. DOI: 10.1016/s0928-0987(01)00209-3. View

15.

Warner J, Price J, Soothill J, Hey E . Controlled trial of hyposensitisation to Dermatophagoides pteronyssinus in children with asthma. Lancet. 1978; 2(8096):912-5. DOI: 10.1016/s0140-6736(78)91630-6. View

16.

Winkler P, Ghadimi D, Schrezenmeir J, Kraehenbuhl J . Molecular and cellular basis of microflora-host interactions. J Nutr. 2007; 137(3 Suppl 2):756S-72S. DOI: 10.1093/jn/137.3.756S. View

17.

Taylor J, Martinez R, Titcombe P, Barsness L, Thomas S, Zhang N . Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen. J Exp Med. 2012; 209(11):2065-77. PMC: 3478923. DOI: 10.1084/jem.20112272. View

18.

Glover M, Atherton D . A double-blind controlled trial of hyposensitization to Dermatophagoides pteronyssinus in children with atopic eczema. Clin Exp Allergy. 1992; 22(4):440-6. DOI: 10.1111/j.1365-2222.1992.tb00145.x. View

19.

Jongejan L, van Ree R . Modified allergens and their potential to treat allergic disease. Curr Allergy Asthma Rep. 2014; 14(12):478. DOI: 10.1007/s11882-014-0478-9. View

20.

Galli E, Chini L, Nardi S, Benincori N, Panei P, Fraioli G . Use of a specific oral hyposensitization therapy to Dermatophagoides pteronyssinus in children with atopic dermatitis. Allergol Immunopathol (Madr). 1994; 22(1):18-22. View