The Rat Closely Mimics Oxidative Stress and Inflammation in Humans After Exercise but Not After Exercise Combined with Vitamin C Administration

Overview

Journal Eur J Appl Physiol

Specialty Physiology

Date 2016 Feb 10

PMID 26856335

Citations 11

Authors

Aristidis S Veskoukis

Georgios Goutianos

Vassilis Paschalis

Nikos V Margaritelis

Aikaterini Tzioura

Konstantina Dipla

Andreas Zafeiridis

Ioannis S Vrabas

Antonios Kyparos

Michalis G Nikolaidis

Affiliations

Soon will be listed here.

Abstract

Purpose: The purpose of the present study was to directly compare oxidative stress and inflammation responses between rats and humans.

Methods: We contrasted rat and human oxidative stress and inflammatory responses to exercise (pro-oxidant stimulus) and/or vitamin C (anti-oxidant stimulus) administration. Vitamin C was administered orally in both species (16 mg kg(-1) of body weight). Twelve redox biomarkers and seven inflammatory biomarkers were determined in plasma and erythrocytes pre- and post-exercise or pre- and post-exercise combined with vitamin C administration.

Results: Exercise increased oxidative stress and induced an inflammatory state in rats and humans. There were only 1/19 significant species × exercise interactions (catalase), indicating similar responses to exercise between rats and humans in redox and inflammatory biomarkers. Vitamin C decreased oxidative stress and increased antioxidant capacity only in humans and did not affect the redox state of rats. In contrast, vitamin C induced an anti-inflammatory state only in rats and did not affect the inflammatory state of humans. There were 10/19 significant species × vitamin C interactions, indicating that rats poorly mimic human oxidative stress and inflammatory responses to vitamin C administration. Exercise after acute vitamin C administration altered redox state only in humans and did not affect the redox state of rats. On the contrary, inflammation biomarkers changed similarly after exercise combined with vitamin C in both rats and humans.

Conclusions: The rat adequately mimics human responses to exercise in basic blood redox/inflammatory profile, yet this is not the case after exercise combined with vitamin C administration.

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