Respiratory Mechanics in Brain Injury: A Review

Overview

Journal World J Crit Care Med

Publisher Baishideng Publishing Group

Specialty Critical Care

Date 2016 Feb 9

PMID 26855895

Citations 19

Authors

Antonia Koutsoukou

Maria Katsiari

Stylianos E Orfanos

Anastasia Kotanidou

Maria Daganou

Magdalini Kyriakopoulou

Nikolaos G Koulouris

Nikoletta Rovina

Affiliations

Soon will be listed here.

Abstract

Several clinical and experimental studies have shown that lung injury occurs shortly after brain damage. The responsible mechanisms involve neurogenic pulmonary edema, inflammation, the harmful action of neurotransmitters, or autonomic system dysfunction. Mechanical ventilation, an essential component of life support in brain-damaged patients (BD), may be an additional traumatic factor to the already injured or susceptible to injury lungs of these patients thus worsening lung injury, in case that non lung protective ventilator settings are applied. Measurement of respiratory mechanics in BD patients, as well as assessment of their evolution during mechanical ventilation, may lead to preclinical lung injury detection early enough, allowing thus the selection of the appropriate ventilator settings to avoid ventilator-induced lung injury. The aim of this review is to explore the mechanical properties of the respiratory system in BD patients along with the underlying mechanisms, and to translate the evidence of animal and clinical studies into therapeutic implications regarding the mechanical ventilation of these critically ill patients.

Citing Articles

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