Effects of Deep Brain Stimulation on Pausing During Spontaneous Speech in Parkinson's Disease

Overview

Journal J Med Speech Lang Pathol

Specialty Otorhinolaryngology

Date 2016 Feb 6

PMID 26848252

Citations 10

Authors

Ji Sook Ahn

Diana Van Lancker Sidtis

John J Sidtis

Affiliations

Soon will be listed here.

Abstract

The present study examined pausing patterns in spontaneous speech as a measure of the effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) on parkinsonian speech. Pauses reflect various aspects of speech and language processes, including motor initiation and linguistic planning. Relatively little attention has been given to pauses in determining the effect of STN-DBS. An examination of pausing may be helpful to understanding how this form of therapy affects these behaviors. Seven individuals with Parkinson's disease who received surgery for bilateral STN-DBS participated. Spontaneous speech samples were elicited in both the ON and OFF STN-DBS condition. Findings indicated that long pauses (250-3000 ms) in spontaneous speech were significantly shorter and more frequent in the STN-DBS ON condition. Furthermore, the proportion of nonlinguistic boundary pauses was significantly greater with stimulation. The findings support previous studies suggesting that speech motor control and lexical retrieval may be affected by STN-DBS.

Citing Articles

Speech, voice, and language outcomes following deep brain stimulation: A systematic review.

Tabari F, Berger J, Flouty O, Copeland B, Greenlee J, Johari K PLoS One. 2024; 19(5):e0302739.

PMID: 38728329 PMC: 11086900. DOI: 10.1371/journal.pone.0302739.

Pausing before verb production is associated with mild cognitive impairment in Parkinson's disease.

Nascimento Andrade E, Manxhari C, Smith K Front Hum Neurosci. 2023; 17:1102024.

PMID: 37113321 PMC: 10126398. DOI: 10.3389/fnhum.2023.1102024.

Stimulation of the Subthalamic Nucleus Changes Cortical-Subcortical Blood Flow Patterns During Speech: A Positron Emission Tomography Study.

Sidtis J, Sidtis D, Dhawan V, Tagliati M, Eidelberg D Front Neurol. 2021; 12:684596.

PMID: 34122323 PMC: 8187801. DOI: 10.3389/fneur.2021.684596.

Impact of deep brain stimulation of the subthalamic nucleus on natural language in patients with Parkinson's disease.

Ehlen F, Al-Fatly B, Kuhn A, Klostermann F PLoS One. 2020; 15(12):e0244148.

PMID: 33373418 PMC: 7771859. DOI: 10.1371/journal.pone.0244148.

Speech Intelligibility During Clinical and Low Frequency.

Sidtis J, Sidtis D, Ramdhani R, Tagliati M Brain Sci. 2020; 10(1).

PMID: 31906549 PMC: 7016584. DOI: 10.3390/brainsci10010026.

References

Guo L, Tomblin J, Samelson V . Speech disruptions in the narratives of English-speaking children with specific language impairment. J Speech Lang Hear Res. 2008; 51(3):722-38. PMC: 2558670. DOI: 10.1044/1092-4388(2008/051). View

Romito L, Scerrati M, Contarino M, Iacoangeli M, Bentivoglio A, Albanese A . Bilateral high frequency subthalamic stimulation in Parkinson's disease: long-term neurological follow-up. J Neurosurg Sci. 2003; 47(3):119-28. View

Hartelius L, Svensson P . Speech and swallowing symptoms associated with Parkinson's disease and multiple sclerosis: a survey. Folia Phoniatr Logop. 1994; 46(1):9-17. DOI: 10.1159/000266286. View

Krystkowiak P, Blatt J, Bourriez J, Duhamel A, Perina M, Blond S . Effects of subthalamic nucleus stimulation and levodopa treatment on gait abnormalities in Parkinson disease. Arch Neurol. 2003; 60(1):80-4. DOI: 10.1001/archneur.60.1.80. View

Jin X, Costa R . Start/stop signals emerge in nigrostriatal circuits during sequence learning. Nature. 2010; 466(7305):457-62. PMC: 3477867. DOI: 10.1038/nature09263. View

Gentil M, Pinto S, Pollak P, Benabid A . Effect of bilateral stimulation of the subthalamic nucleus on parkinsonian dysarthria. Brain Lang. 2003; 85(2):190-6. DOI: 10.1016/s0093-934x(02)00590-4. View

Graybiel A . The basal ganglia and the initiation of movement. Rev Neurol (Paris). 1990; 146(10):570-4. View

Whelan B, Murdoch B, Theodoros D, Hall B, Silburn P . Defining a role for the subthalamic nucleus within operative theoretical models of subcortical participation in language. J Neurol Neurosurg Psychiatry. 2003; 74(11):1543-50. PMC: 1738254. DOI: 10.1136/jnnp.74.11.1543. View

BOOMER D . Hesitation and grammatical encoding. Lang Speech. 1965; 8(3):148-58. DOI: 10.1177/002383096500800302. View

10.

Gentil M, Garcia-Ruiz P, Pollak P, Benabid A . Effect of bilateral deep-brain stimulation on oral control of patients with parkinsonism. Eur Neurol. 2000; 44(3):147-52. DOI: 10.1159/000008224. View

11.

Grossman M . Sentence processing in Parkinson's disease. Brain Cogn. 1999; 40(2):387-413. DOI: 10.1006/brcg.1999.1087. View

12.

Skodda S, Schlegel U . Speech rate and rhythm in Parkinson's disease. Mov Disord. 2008; 23(7):985-992. DOI: 10.1002/mds.21996. View

13.

Romito L, Scerrati M, Contarino M, Bentivoglio A, Tonali P, Albanese A . Long-term follow up of subthalamic nucleus stimulation in Parkinson's disease. Neurology. 2002; 58(10):1546-50. DOI: 10.1212/wnl.58.10.1546. View

14.

Ogar J, Slama H, Dronkers N, Amici S, Gorno-Tempini M . Apraxia of speech: an overview. Neurocase. 2006; 11(6):427-32. DOI: 10.1080/13554790500263529. View

15.

Coates C, Bakheit A . The prevalence of verbal communication disability in patients with Parkinson's disease. Disabil Rehabil. 1997; 19(3):104-7. DOI: 10.3109/09638289709166834. View

16.

Kumar R, Lozano A, Kim Y, Hutchison W, Sime E, Halket E . Double-blind evaluation of subthalamic nucleus deep brain stimulation in advanced Parkinson's disease. Neurology. 1998; 51(3):850-5. DOI: 10.1212/wnl.51.3.850. View

17.

Alegret M, Junque C, Valldeoriola F, Vendrell P, Pilleri M, Rumia J . Effects of bilateral subthalamic stimulation on cognitive function in Parkinson disease. Arch Neurol. 2001; 58(8):1223-7. DOI: 10.1001/archneur.58.8.1223. View

18.

Dujardin K, Defebvre L, Krystkowiak P, Blond S, Destee A . Influence of chronic bilateral stimulation of the subthalamic nucleus on cognitive function in Parkinson's disease. J Neurol. 2001; 248(7):603-11. DOI: 10.1007/s004150170139. View

19.

Green J, Beukelman D, Ball L . Algorithmic Estimation of Pauses in Extended Speech Samples of Dysarthric and Typical Speech. J Med Speech Lang Pathol. 2010; 12(4):149-154. PMC: 2902000. View

20.

Gentil M, Garcia-Ruiz P, Pollak P, Benabid A . Effect of stimulation of the subthalamic nucleus on oral control of patients with parkinsonism. J Neurol Neurosurg Psychiatry. 1999; 67(3):329-33. PMC: 1736540. DOI: 10.1136/jnnp.67.3.329. View