Experimental Biology for the Identification of Causal Pathways in Atherosclerosis

Overview

Journal Cardiovasc Drugs Ther

Specialties Cardiology & Vascular Diseases
Pharmacology

Date 2016 Feb 6

PMID 26847647

Citations 4

Authors

Yanhong Guo

Minerva T Garcia-Barrio

Laiyuan Wang

Y Eugene Chen

Affiliations

Soon will be listed here.

Abstract

More than 60 genomic loci have been implicated by genome-wide association studies (GWAS) and exome-wide association studies as conferring an increased risk of myocardial infarction and coronary artery disease (CAD). However, the causal gene and variant is often unclear. Using the functional analysis of genetic variants in experimental animal models, we anticipate understanding which candidate gene at a specific locus is associated with atherosclerosis and revealing the underlying molecular and cellular mechanisms, ultimately leading to the identification of causal pathways in atherosclerosis and may provide novel therapeutic targets for the treatment of atherosclerotic cardiovascular disease.

Citing Articles

Association of Common Variants of , , and the 9p21.3 Chromosomal Region with the Risk of Myocardial Infarction: A Prospective Study.

Semaev S, Shakhtshneider E, Shcherbakova L, Orlov P, Ivanoshchuk D, Malyutina S Int J Mol Sci. 2023; 24(13).

PMID: 37446094 PMC: 10342168. DOI: 10.3390/ijms241310908.

Association of Pericardiac Adipose Tissue With Coronary Artery Disease.

Li M, Qi L, Li Y, Zhang S, Lin L, Zhou L Front Endocrinol (Lausanne). 2021; 12:724859.

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Analysis of Polymorphism rs1333049 (Located at 9P21.3) in the White Population of Western Siberia and Associations with Clinical and Biochemical Markers.

Shakhtshneider E, Orlov P, Semaev S, Ivanoshchuk D, Malyutina S, Gafarov V Biomolecules. 2019; 9(7).

PMID: 31330999 PMC: 6681349. DOI: 10.3390/biom9070290.

Krüppel-like factor 14, a coronary artery disease associated transcription factor, inhibits endothelial inflammation via NF-κB signaling pathway.

Hu W, Lu H, Zhang J, Fan Y, Chang Z, Liang W Atherosclerosis. 2018; 278:39-48.

PMID: 30248551 PMC: 6441279. DOI: 10.1016/j.atherosclerosis.2018.09.018.

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