Hepatitis B Virus X Protein Reduces the Stability of Nrdp1 to Up-regulate ErbB3 in Hepatocellular Carcinoma Cells

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2016 Feb 6

PMID 26846102

Citations 9

Authors

Kuan Cao

Hui Gong

Zhichao Qiu

Quan Wen

Bin Zhang

Tianjin Tang

Xinyu Zhou

Tong Cao

Bin Wang

Hengliang Shi

Renhao Wang

Affiliations

Soon will be listed here.

Abstract

Hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) is the most widespread type of liver cancer. However, the underlying mechanism of HCC tumorigenesis is very intricate and HBV-encoded X protein (HBx) has been reported to play a key role in this process. It has been reported that HBx up-regulates the transcription of ErbB3. However, it remains unclear whether HBx can regulate ErbB3 expression at post-translational modification level. In this study, we showed that HBx interacts with ubiquitin ligase Nrdp1 (neuregulin receptor degradation protein 1) and decreases its stability, which results in the up-regulation of ErbB3 and promotion of HCC cells. Moreover, the expression of ErbB3 was almost undetectable in normal liver tissues but was relative abundant in HCC tissues, and the level of ErbB3 and Nrdp1 significantly showed a negative correlation in HCC tissues. Taken together, these findings suggest that HBx promotes the progression of HCC by decreasing the stability of Nrdp1, which results in up-regulation of ErbB3, suggesting that ErbB3 may be a target for HCC therapy.

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