Early Somatostatin Interneuron Connectivity Mediates the Maturation of Deep Layer Cortical Circuits

Overview

Journal Neuron

Publisher Cell Press

Specialty Neurology

Date 2016 Feb 5

PMID 26844832

Citations 106

Authors

Sebnem N Tuncdemir

Brie Wamsley

Floor J Stam

Fumitaka Osakada

Martyn Goulding

Edward M Callaway

Bernardo Rudy

Gord Fishell

Affiliations

Soon will be listed here.

Abstract

The precise connectivity of somatostatin and parvalbumin cortical interneurons is generated during development. An understanding of how these interneuron classes incorporate into cortical circuitry is incomplete but essential to elucidate the roles they play during maturation. Here, we report that somatostatin interneurons in infragranular layers receive dense but transient innervation from thalamocortical afferents during the first postnatal week. During this period, parvalbumin interneurons and pyramidal neurons within the same layers receive weaker thalamocortical inputs, yet are strongly innervated by somatostatin interneurons. Further, upon disruption of the early (but not late) somatostatin interneuron network, the synaptic maturation of thalamocortical inputs onto parvalbumin interneurons is perturbed. These results suggest that infragranular somatostatin interneurons exhibit a transient early synaptic connectivity that is essential for the establishment of thalamic feedforward inhibition mediated by parvalbumin interneurons.

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