Atrial Fibrillation Associated with Acute Pancreatitis: a Retrospective Cohort Study in Taiwan

Background: There is little data on the relationship between atrial fibrillation and acute pancreatitis. The aim of this study was to evaluate whether atrial fibrillation is associated with acute pancreatitis.

Methods: This retrospective cohort study analyzed the database of the Taiwan National Health Insurance Program from 2000 to 2010. There were 8,981 subjects aged 20-84 with newly diagnosed atrial fibrillation as the atrial fibrillation group and 26,643 sex- and age-matched, randomly selected subjects without atrial fibrillation as the non-atrial fibrillation group. We used the multivariable Cox proportional hazards regression model to measure the hazard ratio (HR) and 95% confidence interval (CI) for acute pancreatitis risk associated with atrial fibrillation and other comorbidities.

Results: The crude incidence rates of acute pancreatitis were 3.07 per 1,000 person-years in the atrial fibrillation group and 2.03 per 1,000 person-years in the non-atrial fibrillation group (incidence rate ratio 1.51, 95% CI 1.40, 1.63). After controlling for potential confounding factors, the adjusted HR of acute pancreatitis was 1.46 for the atrial fibrillation group, as compared with the non-atrial fibrillation group (95% CI 1.18, 1.80). In further analysis, even in the absence of alcohol-related disease and biliary stone, the adjusted HR of acute pancreatitis was 1.62 for the atrial fibrillation group, as compared with the non-atrial fibrillation group (95% CI 1.24, 2.12).

Conclusions: Atrial fibrillation is associated with acute pancreatitis in the Taiwanese population, even in the absence of alcohol-related disease and biliary stone. Further research is necessary to explore the pathogenesis underlying the relationship between atrial fibrillation and acute pancreatitis.