Synthesis and In Vitro Biological Evaluation of 1,3,4-Oxadiazol-2(3H)-one and Tetrahydropyridazine-3,6-dione Derivatives of Fatty Acids

Overview

Journal Sci Pharm

Publisher MDPI

Specialty Pharmacology

Date 2016 Feb 4

PMID 26839828

Citations 1

Authors

Mohammad F Hassan

Abdul Rauf

Asif Sherwani

Mohammad Owais

Affiliations

Soon will be listed here.

Abstract

Herein we report saturated and unsaturated fatty acid derivatives of 1,3,4-oxadiazol-2(3H)-one and tetrahydropyridazine-3,6-dione as new potential anticancer agents. All the synthesised compounds were characterised by IR, (1)H-NMR, (13)C-NMR, and mass spectral data. The relative sensitivity of three cancer cell lines varied depending on the nature of the compound. Among the most effective anticancer compounds studied, 3b and 6b displayed remarkable anticancer activity against the MDA-MB-231 and KCL-22 lines, respectively. On the other hand, compound 3c was found to be most sensitive to nearly all the tested cell lines, MDA-MB-231, KCL-22, and HeLa.

Citing Articles

Groundbreaking Anticancer Activity of Highly Diversified Oxadiazole Scaffolds.

Benassi A, Doria F, Pirota V Int J Mol Sci. 2020; 21(22).

PMID: 33217987 PMC: 7698752. DOI: 10.3390/ijms21228692.

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