Epigenetic Reprogramming of Muscle Progenitors: Inspiration for Clinical Therapies

Overview

Journal Stem Cells Int

Publisher Wiley

Specialty Cell Biology

Date 2016 Feb 4

PMID 26839565

Citations 12

Authors

Silvia Consalvi

Martina Sandona

Valentina Saccone

Affiliations

Soon will be listed here.

Abstract

In the context of regenerative medicine, based on the potential of stem cells to restore diseased tissues, epigenetics is becoming a pivotal area of interest. Therapeutic interventions that promote tissue and organ regeneration have as primary objective the selective control of gene expression in adult stem cells. This requires a deep understanding of the epigenetic mechanisms controlling transcriptional programs in tissue progenitors. This review attempts to elucidate the principle epigenetic regulations responsible of stem cells differentiation. In particular we focus on the current understanding of the epigenetic networks that regulate differentiation of muscle progenitors by the concerted action of chromatin-modifying enzymes and noncoding RNAs. The novel exciting role of exosome-bound microRNA in mediating epigenetic information transfer is also discussed. Finally we show an overview of the epigenetic strategies and therapies that aim to potentiate muscle regeneration and counteract the progression of Duchenne Muscular Dystrophy (DMD).

Citing Articles

Histone Deacetylases: Molecular Mechanisms and Therapeutic Implications for Muscular Dystrophies.

Sandona M, Cavioli G, Renzini A, Cedola A, Gigli G, Coletti D Int J Mol Sci. 2023; 24(5).

PMID: 36901738 PMC: 10002075. DOI: 10.3390/ijms24054306.

Epigenetic reprogramming of cell identity: lessons from development for regenerative medicine.

Basu A, Tiwari V Clin Epigenetics. 2021; 13(1):144.

PMID: 34301318 PMC: 8305869. DOI: 10.1186/s13148-021-01131-4.

Dobrowolny G, Barbiera A, Sica G, Scicchitano B Cells. 2021; 10(6).

PMID: 34074012 PMC: 8225025. DOI: 10.3390/cells10061307.

Pluripotent stem cell-induced skeletal muscle progenitor cells with givinostat promote myoangiogenesis and restore dystrophin in injured Duchenne dystrophic muscle.

Xuan W, Khan M, Ashraf M Stem Cell Res Ther. 2021; 12(1):131.

PMID: 33579366 PMC: 7881535. DOI: 10.1186/s13287-021-02174-3.

Epigenetic modifications in muscle regeneration and progression of Duchenne muscular dystrophy.

Rugowska A, Starosta A, Konieczny P Clin Epigenetics. 2021; 13(1):13.

PMID: 33468200 PMC: 7814631. DOI: 10.1186/s13148-021-01001-z.

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