Reducing Central Serotonin in Adulthood Promotes Hippocampal Neurogenesis

Overview

Journal Sci Rep

Specialty Science

Date 2016 Feb 4

PMID 26839004

Citations 31

Authors

Ning-Ning Song

Yun-Fang Jia

Lei Zhang

Qiong Zhang

Ying Huang

Xiao-Zhen Liu

Ling Hu

Wei Lan

Ling Chen

Klaus-Peter Lesch

Xiaoyan Chen

Lin Xu

Yu-Qiang Ding

Affiliations

Soon will be listed here.

Abstract

Chronic administration of selective serotonin reuptake inhibitors (SSRIs), which up-regulates central serotonin (5-HT) system function, enhances adult hippocampal neurogenesis. However, the relationship between central 5-HT system and adult neurogenesis has not fully been understood. Here, we report that lowering 5-HT level in adulthood is also able to enhance adult hippocampal neurogenesis. We used tamoxifen (TM)-induced Cre in Pet1-CreER(T2) mice to either deplete central serotonergic (5-HTergic) neurons or inactivate 5-HT synthesis in adulthood and explore the role of central 5-HT in adult hippocampal neurogenesis. A dramatic increase in hippocampal neurogenesis is present in these two central 5-HT-deficient mice and it is largely prevented by administration of agonist for 5-HTR2c receptor. In addition, the survival of new-born neurons in the hippocampus is enhanced. Furthermore, the adult 5-HT-deficient mice showed reduced depression-like behaviors but enhanced contextual fear memory. These findings demonstrate that lowering central 5-HT function in adulthood can also enhance adult hippocampal neurogenesis, thus revealing a new aspect of central 5-HT in regulating adult neurogenesis.

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