Regulatory Crosstalk by Protein Kinases on CFTR Trafficking and Activity

Overview

Journal Front Chem

Specialty Chemistry

Date 2016 Feb 3

PMID 26835446

Citations 18

Authors

Carlos M Farinha

Agnieszka Swiatecka-Urban

David L Brautigan

Peter Jordan

Affiliations

Soon will be listed here.

Abstract

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a member of the ATP binding cassette (ABC) transporter superfamily that functions as a cAMP-activated chloride ion channel in fluid-transporting epithelia. There is abundant evidence that CFTR activity (i.e., channel opening and closing) is regulated by protein kinases and phosphatases via phosphorylation and dephosphorylation. Here, we review recent evidence for the role of protein kinases in regulation of CFTR delivery to and retention in the plasma membrane. We review this information in a broader context of regulation of other transporters by protein kinases because the overall functional output of transporters involves the integrated control of both their number at the plasma membrane and their specific activity. While many details of the regulation of intracellular distribution of CFTR and other transporters remain to be elucidated, we hope that this review will motivate research providing new insights into how protein kinases control membrane transport to impact health and disease.

Citing Articles

Cell type-specific regulation of CFTR trafficking-on the verge of progress.

Farinha C, Santos L, Ferreira J Front Cell Dev Biol. 2024; 12:1338892.

PMID: 38505263 PMC: 10949533. DOI: 10.3389/fcell.2024.1338892.

SUMOylation Inhibition Enhances Protein Transcription under CMV Promoter: A Lesson from a Study with the F508del-CFTR Mutant.

Borgo C, DAmore C, Capurro V, Tomati V, Pedemonte N, Bosello Travain V Int J Mol Sci. 2024; 25(4).

PMID: 38396982 PMC: 10889535. DOI: 10.3390/ijms25042302.

Clinical Consequences and Functional Impact of the Rare S737F CFTR Variant and Its Responsiveness to CFTR Modulators.

Terlizzi V, Pesce E, Capurro V, Tomati V, Lena M, Pastorino C Int J Mol Sci. 2023; 24(7).

PMID: 37047546 PMC: 10095403. DOI: 10.3390/ijms24076576.

KDM2A and KDM3B as Potential Targets for the Rescue of F508del-CFTR.

DAmore C, Borgo C, Bosello Travain V, Salvi M Int J Mol Sci. 2022; 23(17).

PMID: 36077010 PMC: 9455907. DOI: 10.3390/ijms23179612.

Revisiting CFTR Interactions: Old Partners and New Players.

Farinha C, Gentzsch M Int J Mol Sci. 2021; 22(24).

PMID: 34947992 PMC: 8703571. DOI: 10.3390/ijms222413196.

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