Recurrent Wheezing in Children

Overview

Journal Transl Pediatr

Publisher AME Publishing Company

Specialty Pediatrics

Date 2016 Feb 3

PMID 26835404

Citations 17

Authors

Laura Tenero

Michele Piazza

Giorgio Piacentini

Affiliations

Soon will be listed here.

Abstract

Recurrent wheezing have a significant morbidity and it's estimated that about one third of school-age children manifest the symptom during the first 5 years of life. Proper identification of children at risk of developing asthma at school age may predict long-term outcomes and improve treatment and preventive approach, but the possibility to identify these children at preschool age remains limited. For many years authors focused their studies to identify early children with recurrent wheezing at risk to develop asthma at school age. Different phenotypes have been proposed for a more precise characterization and a personalized plan of treatment. The main criticism concerns the inability to define stable phenotypes with the risk of overestimating or underestimating the characteristics of symptoms in these children. The aim of this review is to report the recent developments on the diagnosis and treatment of recurrent paediatric wheezing.

Citing Articles

Association of humidity and precipitation with asthma: a systematic review and meta-analysis.

Gu W, Xie D, Li Q, Feng H, Xue Y, Chen Y Front Allergy. 2024; 5:1483430.

PMID: 39713043 PMC: 11659254. DOI: 10.3389/falgy.2024.1483430.

A smartphone app for preschool wheezing and reliability of medical history collection.

Ullmann N, Fracchiolla A, Boni A, Negro V, Porcaro F, Di Marco A Ital J Pediatr. 2024; 50(1):220.

PMID: 39456090 PMC: 11515270. DOI: 10.1186/s13052-024-01792-w.

Environmental exposures associated with early childhood recurrent wheezing in the mother and child in the environment birth cohort: a time-to-event study.

Asharam K, Mitku A, Ramsay L, Jeena P, Naidoo R Thorax. 2024; 79(10):953-960.

PMID: 38964859 PMC: 11503139. DOI: 10.1136/thorax-2023-221150.

Vitamin D Level and Immune Modulation in Children with Recurrent Wheezing.

Feketea G, Vassilopoulou E, Andreescu O, Berghea E, Pop R, Sabin O Children (Basel). 2024; 11(2).

PMID: 38397331 PMC: 10888088. DOI: 10.3390/children11020219.

Effects and safety of hypertonic saline combined with airway clearance in non-hospitalized children with recurrent wheezing.

Gonzalez-Bellido V, Velaz-Baza V, Rama-Suarez N, Jimeno-Esteo C, Sirvent-Gomez J, Cuenca-Zaldivar J Hong Kong Physiother J. 2023; 43(2):105-115.

PMID: 37583920 PMC: 10423675. DOI: 10.1142/S1013702523500105.

References

Stein R, Sherrill D, Morgan W, Holberg C, Halonen M, Taussig L . Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet. 1999; 354(9178):541-5. DOI: 10.1016/S0140-6736(98)10321-5. View

Castro-Rodriguez J, Holberg C, Wright A, Martinez F . A clinical index to define risk of asthma in young children with recurrent wheezing. Am J Respir Crit Care Med. 2000; 162(4 Pt 1):1403-6. DOI: 10.1164/ajrccm.162.4.9912111. View

Brand P, Baraldi E, Bisgaard H, Boner A, Castro-Rodriguez J, Custovic A . Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach. Eur Respir J. 2008; 32(4):1096-110. DOI: 10.1183/09031936.00002108. View

Garcia-Marcos L, Mallol J, Sole D, Brand P . International study of wheezing in infants: risk factors in affluent and non-affluent countries during the first year of life. Pediatr Allergy Immunol. 2010; 21(5):878-88. DOI: 10.1111/j.1399-3038.2010.01035.x. View

Mallol J, Garcia-Marcos L, Sole D, Brand P . International prevalence of recurrent wheezing during the first year of life: variability, treatment patterns and use of health resources. Thorax. 2010; 65(11):1004-9. DOI: 10.1136/thx.2009.115188. View

Ducharme F, Tse S, Chauhan B . Diagnosis, management, and prognosis of preschool wheeze. Lancet. 2014; 383(9928):1593-604. DOI: 10.1016/S0140-6736(14)60615-2. View

Pescatore A, Dogaru C, Duembgen L, Silverman M, Gaillard E, Spycher B . A simple asthma prediction tool for preschool children with wheeze or cough. J Allergy Clin Immunol. 2013; 133(1):111-8.e1-13. DOI: 10.1016/j.jaci.2013.06.002. View

Martinez F . What have we learned from the Tucson Children's Respiratory Study?. Paediatr Respir Rev. 2002; 3(3):193-7. DOI: 10.1016/s1526-0542(02)00188-4. View

Ghirga G, Ghirga P, Fagioli S, Colaiacomo M . Intermittent treatment with high dose nebulized beclomethasone for recurrent wheezing in infants due to upper respiratory tract infection. Minerva Pediatr. 2002; 54(3):217-20. View

10.

Soutar A, Seaton A, Brown K . Bronchial reactivity and dietary antioxidants. Thorax. 1997; 52(2):166-70. PMC: 1758477. DOI: 10.1136/thx.52.2.166. View

11.

Martinez F, Wright A, Taussig L, Holberg C, Halonen M, Morgan W . Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med. 1995; 332(3):133-8. DOI: 10.1056/NEJM199501193320301. View

12.

Castro-Rodriguez J . The Asthma Predictive Index: early diagnosis of asthma. Curr Opin Allergy Clin Immunol. 2011; 11(3):157-61. DOI: 10.1097/ACI.0b013e3283464c4a. View

13.

Celedon J, Litonjua A, Ryan L, Weiss S, Gold D . Bottle feeding in the bed or crib before sleep time and wheezing in early childhood. Pediatrics. 2002; 110(6):e77. DOI: 10.1542/peds.110.6.e77. View

14.

Wanner A, Horvath G, Brieva J, Kumar S, Mendes E . Nongenomic actions of glucocorticosteroids on the airway vasculature in asthma. Proc Am Thorac Soc. 2005; 1(3):235-8. DOI: 10.1513/pats.200402-013MS. View

15.

Heroux M, Braubach M, Korol N, Krzyzanowski M, Paunovic E, Zastenskaya I . [The main conclusions about the medical aspects of air pollution: the projects REVIHAAP and HRAPIE WHO/EC]. Gig Sanit. 2014; (6):9-14. View

16.

Savenije O, Mahachie John J, Granell R, Kerkhof M, Dijk F, de Jongste J . Association of IL33-IL-1 receptor-like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood. J Allergy Clin Immunol. 2014; 134(1):170-7. DOI: 10.1016/j.jaci.2013.12.1080. View

17.

Yang K, Ou C, Chang J, Chen R, Liu C, Liang H . Infant frequent wheezing correlated to Clara cell protein 10 (CC10) polymorphism and concentration, but not allergy sensitization, in a perinatal cohort study. J Allergy Clin Immunol. 2007; 120(4):842-8. DOI: 10.1016/j.jaci.2007.07.009. View

18.

Gilmour M, Jaakkola M, London S, Nel A, Rogers C . How exposure to environmental tobacco smoke, outdoor air pollutants, and increased pollen burdens influences the incidence of asthma. Environ Health Perspect. 2006; 114(4):627-33. PMC: 1440792. DOI: 10.1289/ehp.8380. View

19.

Ducharme F, Lemire C, Noya F, Davis G, Alos N, Leblond H . Preemptive use of high-dose fluticasone for virus-induced wheezing in young children. N Engl J Med. 2009; 360(4):339-53. DOI: 10.1056/NEJMoa0808907. View

20.

Savenije O, Kerkhof M, Koppelman G, Postma D . Predicting who will have asthma at school age among preschool children. J Allergy Clin Immunol. 2012; 130(2):325-31. DOI: 10.1016/j.jaci.2012.05.007. View