Tuberculosis and Cardiovascular Disease: Linking the Epidemics

Overview

Journal Trop Dis Travel Med Vaccines

Publisher Biomed Central

Specialty Infectious Diseases

Date 2016 Feb 3

PMID 26835156

Citations 52

Authors

Moises A Huaman

David Henson

Eduardo Ticona

Timothy R Sterling

Beth A Garvy

Affiliations

Soon will be listed here.

Abstract

The burden of tuberculosis and cardiovascular disease (CVD) is enormous worldwide. CVD rates are rapidly increasing in low- and middle-income countries. Public health programs have been challenged with the overlapping tuberculosis and CVD epidemics. Monocyte/macrophages, lymphocytes and cytokines involved in cellular mediated immune responses against are also main drivers of atherogenesis, suggesting a potential pathogenic role of tuberculosis in CVD via mechanisms that have been described for other pathogens that establish chronic infection and latency. Studies have shown a pro-atherogenic effect of antibody-mediated responses against mycobacterial heat shock protein-65 through cross reaction with self-antigens in human vessels. Furthermore, subsets of mycobacteria actively replicate during latent tuberculosis infection (LTBI), and recent studies suggest that LTBI is associated with persistent chronic inflammation that may lead to CVD. Recent epidemiologic work has shown that the risk of CVD in persons who develop tuberculosis is higher than in persons without a history of tuberculosis, even several years after recovery from tuberculosis. Together, these data suggest that tuberculosis may play a role in the pathogenesis of CVD. Further research to investigate a potential link between tuberculosis and CVD is warranted.

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References

Marais B, Lonnroth K, Lawn S, Migliori G, Mwaba P, Glaziou P . Tuberculosis comorbidity with communicable and non-communicable diseases: integrating health services and control efforts. Lancet Infect Dis. 2013; 13(5):436-48. DOI: 10.1016/S1473-3099(13)70015-X. View

Wallis P, Branfoot A, EMERSON P . Sudden death due to myocardial tuberculosis. Thorax. 1984; 39(2):155-6. PMC: 459744. DOI: 10.1136/thx.39.2.155. View

Blessing E, Campbell L, Rosenfeld M, Chough N, Kuo C . Chlamydia pneumoniae infection accelerates hyperlipidemia induced atherosclerotic lesion development in C57BL/6J mice. Atherosclerosis. 2001; 158(1):13-7. DOI: 10.1016/s0021-9150(00)00758-9. View

Cowan J, Pandey S, Filion L, Angel J, Kumar A, Cameron D . Comparison of interferon-γ-, interleukin (IL)-17- and IL-22-expressing CD4 T cells, IL-22-expressing granulocytes and proinflammatory cytokines during latent and active tuberculosis infection. Clin Exp Immunol. 2012; 167(2):317-29. PMC: 3278699. DOI: 10.1111/j.1365-2249.2011.04520.x. View

Zhu J, Katz R, Quyyumi A, Canos D, Rott D, Csako G . Association of serum antibodies to heat-shock protein 65 with coronary calcification levels: suggestion of pathogen-triggered autoimmunity in early atherosclerosis. Circulation. 2003; 109(1):36-41. DOI: 10.1161/01.CIR.0000105513.37677.B3. View

Sullivan Z, Wong E, Ndungu T, Kasprowicz V, Bishai W . Latent and Active Tuberculosis Infection Increase Immune Activation in Individuals Co-Infected with HIV. EBioMedicine. 2015; 2(4):334-340. PMC: 4476549. DOI: 10.1016/j.ebiom.2015.03.005. View

Falk E . Plaque rupture with severe pre-existing stenosis precipitating coronary thrombosis. Characteristics of coronary atherosclerotic plaques underlying fatal occlusive thrombi. Br Heart J. 1983; 50(2):127-34. PMC: 481384. DOI: 10.1136/hrt.50.2.127. View

Naghavi M, Wyde P, Litovsky S, Madjid M, Akhtar A, Naguib S . Influenza infection exerts prominent inflammatory and thrombotic effects on the atherosclerotic plaques of apolipoprotein E-deficient mice. Circulation. 2003; 107(5):762-8. DOI: 10.1161/01.cir.0000048190.68071.2b. View

Freiberg M, Chang C, Kuller L, Skanderson M, Lowy E, Kraemer K . HIV infection and the risk of acute myocardial infarction. JAMA Intern Med. 2013; 173(8):614-22. PMC: 4766798. DOI: 10.1001/jamainternmed.2013.3728. View

10.

Lockhart E, Green A, Flynn J . IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection. J Immunol. 2006; 177(7):4662-9. DOI: 10.4049/jimmunol.177.7.4662. View

11.

Xu Q, Dietrich H, Steiner H, Gown A, Schoel B, Mikuz G . Induction of arteriosclerosis in normocholesterolemic rabbits by immunization with heat shock protein 65. Arterioscler Thromb. 1992; 12(7):789-99. DOI: 10.1161/01.atv.12.7.789. View

12.

Elizalde J, Perez-Pujol S, Heras M, Sionis A, Casanovas N, Martorell T . Effects of Helicobacter pylori eradication on platelet activation and disease recurrence in patients with acute coronary syndromes. Helicobacter. 2004; 9(6):681-9. DOI: 10.1111/j.1083-4389.2004.00271.x. View

13.

Gaziano T, Bitton A, Anand S, Abrahams-Gessel S, Murphy A . Growing epidemic of coronary heart disease in low- and middle-income countries. Curr Probl Cardiol. 2010; 35(2):72-115. PMC: 2864143. DOI: 10.1016/j.cpcardiol.2009.10.002. View

14.

Zhou Y, Shou M, Guetta E, Guzman R, Unger E, Yu Z . Cytomegalovirus infection of rats increases the neointimal response to vascular injury without consistent evidence of direct infection of the vascular wall. Circulation. 1999; 100(14):1569-75. DOI: 10.1161/01.cir.100.14.1569. View

15.

Walters H, Aguiar C, MacDermott E, Adams A, Barinstein L, Dayton J . Takayasu arteritis presenting in the context of active tuberculosis: a pediatric case. J Clin Rheumatol. 2013; 19(6):344-7. DOI: 10.1097/RHU.0b013e31829ce750. View

16.

Davis J, Ramakrishnan L . The role of the granuloma in expansion and dissemination of early tuberculous infection. Cell. 2009; 136(1):37-49. PMC: 3134310. DOI: 10.1016/j.cell.2008.11.014. View

17.

Wolf A, Linas B, Trevejo-Nunez G, Kincaid E, Tamura T, Takatsu K . Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo. J Immunol. 2007; 179(4):2509-19. DOI: 10.4049/jimmunol.179.4.2509. View

18.

Gupta S, Pablo A, Jiang X, Wang N, Tall A, Schindler C . IFN-gamma potentiates atherosclerosis in ApoE knock-out mice. J Clin Invest. 1997; 99(11):2752-61. PMC: 508122. DOI: 10.1172/JCI119465. View

19.

Moazed T, Campbell L, Rosenfeld M, GRAYSTON J, Kuo C . Chlamydia pneumoniae infection accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. J Infect Dis. 1999; 180(1):238-41. DOI: 10.1086/314855. View

20.

Saikku P, Leinonen M, Tenkanen L, Linnanmaki E, Ekman M, Manninen V . Chronic Chlamydia pneumoniae infection as a risk factor for coronary heart disease in the Helsinki Heart Study. Ann Intern Med. 1992; 116(4):273-8. DOI: 10.7326/0003-4819-116-4-273. View