"Eat Me" Imaging and Therapy

Overview

Journal Adv Drug Deliv Rev

Specialty Pharmacology

Date 2016 Jan 31

PMID 26826436

Citations 21

Authors

Vaishali Bagalkot

Jeffrey A Deiuliis

Sanjay Rajagopalan

Andrei Maiseyeu

Affiliations

Soon will be listed here.

Abstract

Clearance of apoptotic debris is a vital role of the innate immune system. Drawing upon principles of apoptotic clearance, convenient delivery vehicles including intrinsic anti-inflammatory characteristics and specificity to immune cells can be engineered to aid in drug delivery. In this article, we examine the use of phosphatidylserine (PtdSer), the well-known "eat-me" signal, in nanoparticle-based therapeutics making them highly desirable "meals" for phagocytic immune cells. Use of PtdSer facilitates engulfment of nanoparticles allowing for imaging and therapy in various pathologies and may result in immunomodulation. Furthermore, we discuss the targeting of the macrophages and other cells at sites of inflammation in disease. A thorough understanding of the immunobiology of "eat-me" signals is requisite for the successful application of "eat-me"-bearing materials in biomedical applications.

Citing Articles

Enhanced Macrophage Uptake of Spray-Dried Phosphatidylserine-Loaded Microparticles for Pulmonary Drug Delivery Applications.

Freeman M, Parvaresh-Rizi A, Meenach S J Drug Deliv Sci Technol. 2025; 104.

PMID: 39830679 PMC: 11737435. DOI: 10.1016/j.jddst.2024.106535.

A Low-Modulus Phosphatidylserine-Exposing Microvesicle Alleviates Skin Inflammation via Persistent Blockade of M1 Macrophage Polarization.

Zhang Z, Mo Y, Xu S, Jiang L, Peng Y, ZhuGe Y Int J Mol Sci. 2025; 26(1.

PMID: 39796248 PMC: 11720988. DOI: 10.3390/ijms26010394.

Nanoparticle-based itaconate treatment recapitulates low-cholesterol/low-fat diet-induced atherosclerotic plaque resolution.

Hong N, Chaplin A, Di L, Ravodina A, Bevan G, Gao H Cell Rep. 2024; 43(11):114911.

PMID: 39466775 PMC: 11648168. DOI: 10.1016/j.celrep.2024.114911.

"Find Me" and "Eat Me" signals: tools to drive phagocytic processes for modulating antitumor immunity.

Xiao L, Zhang L, Guo C, Xin Q, Gu X, Jiang C Cancer Commun (Lond). 2024; 44(7):791-832.

PMID: 38923737 PMC: 11260773. DOI: 10.1002/cac2.12579.

Don't eat me/eat me signals as a novel strategy in cancer immunotherapy.

Khalaji A, Baharlouei Yancheshmeh F, Farham F, Khorram A, Sheshbolouki S, Zokaei M Heliyon. 2023; 9(10):e20507.

PMID: 37822610 PMC: 10562801. DOI: 10.1016/j.heliyon.2023.e20507.

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