[Research Advances of Anti-tumor Immune Response Induced by Pulse Electric Field Ablation]

Overview

Journal Zhejiang Da Xue Xue Bao Yi Xue Ban

Specialty General Medicine

Date 2016 Jan 30

PMID 26822051

Citations 1

Authors

Guang-Ying Cui

Hong-yan Diao

Affiliations

Soon will be listed here.

Abstract

As a novel tumor therapy, pulse electric field has shown a clinical perspective. This paper reviews the characteristics of tumor ablation by microsecond pulse and nanosecond pulse electric field, and the research advances of anti-tumor immune response induced by pulse electric field ablation. Recent researches indicate that the pulse electric field not only leads to a complete ablation of local tumor, but also stimulates a protective immune response, thereby inhibiting tumor recurrence and metastasis. These unique advantages will show an extensive clinical application in the future. However, the mechanism of anti-tumor immune response and the development of related tumor vaccine need further studies.

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References

Yin S, Chen X, Hu C, Zhang X, Hu Z, Yu J . Nanosecond pulsed electric field (nsPEF) treatment for hepatocellular carcinoma: a novel locoregional ablation decreasing lung metastasis. Cancer Lett. 2014; 346(2):285-91. DOI: 10.1016/j.canlet.2014.01.009. View

Ren Z, Chen X, Cui G, Yin S, Chen L, Jiang J . Nanosecond pulsed electric field inhibits cancer growth followed by alteration in expressions of NF-κB and Wnt/β-catenin signaling molecules. PLoS One. 2013; 8(9):e74322. PMC: 3775773. DOI: 10.1371/journal.pone.0074322. View

Hall E, Schoenbach K, Beebe S . Nanosecond pulsed electric fields (nsPEF) induce direct electric field effects and biological effects on human colon carcinoma cells. DNA Cell Biol. 2005; 24(5):283-91. DOI: 10.1089/dna.2005.24.283. View

Li X, Xu K, Li W, Qiu X, Ma B, Fan Q . Immunologic response to tumor ablation with irreversible electroporation. PLoS One. 2012; 7(11):e48749. PMC: 3490901. DOI: 10.1371/journal.pone.0048749. View

Entin I, Plotnikov A, Korenstein R, Keisari Y . Tumor growth retardation, cure, and induction of antitumor immunity in B16 melanoma-bearing mice by low electric field-enhanced chemotherapy. Clin Cancer Res. 2003; 9(8):3190-7. View

Al-Sakere B, Bernat C, Andre F, Connault E, Opolon P, Davalos R . A study of the immunological response to tumor ablation with irreversible electroporation. Technol Cancer Res Treat. 2007; 6(4):301-6. DOI: 10.1177/153303460700600406. View

Narayanan G, Froud T, Lo K, Barbery K, Perez-Rojas E, Yrizarry J . Pain analysis in patients with hepatocellular carcinoma: irreversible electroporation versus radiofrequency ablation-initial observations. Cardiovasc Intervent Radiol. 2012; 36(1):176-82. DOI: 10.1007/s00270-012-0426-9. View

Chen R, Sain N, Harlow K, Chen Y, Shires P, Heller R . A protective effect after clearance of orthotopic rat hepatocellular carcinoma by nanosecond pulsed electric fields. Eur J Cancer. 2014; 50(15):2705-13. DOI: 10.1016/j.ejca.2014.07.006. View

Yao C, Mi Y, Hu X, Li C, Sun C, Tang J . Experiment and mechanism research of SKOV3 cancer cell apoptosis induced by nanosecond pulsed electric field. Annu Int Conf IEEE Eng Med Biol Soc. 2009; 2008:1044-7. DOI: 10.1109/IEMBS.2008.4649338. View

10.

Thomson K, Cheung W, Ellis S, Federman D, Kavnoudias H, Loader-Oliver D . Investigation of the safety of irreversible electroporation in humans. J Vasc Interv Radiol. 2011; 22(5):611-21. DOI: 10.1016/j.jvir.2010.12.014. View

11.

Beebe S, Fox P, Rec L, Willis E, Schoenbach K . Nanosecond, high-intensity pulsed electric fields induce apoptosis in human cells. FASEB J. 2003; 17(11):1493-5. DOI: 10.1096/fj.02-0859fje. View

12.

Martin 2nd R, McFarland K, Ellis S, Velanovich V . Irreversible electroporation therapy in the management of locally advanced pancreatic adenocarcinoma. J Am Coll Surg. 2012; 215(3):361-9. DOI: 10.1016/j.jamcollsurg.2012.05.021. View

13.

Chen X, Kolb J, Swanson R, Schoenbach K, Beebe S . Apoptosis initiation and angiogenesis inhibition: melanoma targets for nanosecond pulsed electric fields. Pigment Cell Melanoma Res. 2010; 23(4):554-63. DOI: 10.1111/j.1755-148X.2010.00704.x. View

14.

Nuccitelli R, Sheikh S, Tran K, Athos B, Kreis M, Nuccitelli P . Nanoelectroablation therapy for murine basal cell carcinoma. Biochem Biophys Res Commun. 2012; 424(3):446-50. PMC: 3415467. DOI: 10.1016/j.bbrc.2012.06.129. View

15.

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M . Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2014; 136(5):E359-86. DOI: 10.1002/ijc.29210. View

16.

Hall E, Schoenbach K, Beebe S . Nanosecond pulsed electric fields induce apoptosis in p53-wildtype and p53-null HCT116 colon carcinoma cells. Apoptosis. 2007; 12(9):1721-31. DOI: 10.1007/s10495-007-0083-7. View

17.

Pech M, Janitzky A, Wendler J, Strang C, Blaschke S, Dudeck O . Irreversible electroporation of renal cell carcinoma: a first-in-man phase I clinical study. Cardiovasc Intervent Radiol. 2010; 34(1):132-8. DOI: 10.1007/s00270-010-9964-1. View

18.

Nuccitelli R, Pliquett U, Chen X, Ford W, Swanson R, Beebe S . Nanosecond pulsed electric fields cause melanomas to self-destruct. Biochem Biophys Res Commun. 2006; 343(2):351-60. PMC: 1513546. DOI: 10.1016/j.bbrc.2006.02.181. View

19.

Chen X, Zhuang J, Kolb J, Schoenbach K, Beebe S . Long term survival of mice with hepatocellular carcinoma after pulse power ablation with nanosecond pulsed electric fields. Technol Cancer Res Treat. 2011; 11(1):83-93. DOI: 10.7785/tcrt.2012.500237. View

20.

Stacey M, Osgood C, Kalluri B, Cao W, Elsayed-Ali H, Abdel-Fattah T . Nanosecond pulse electrical fields used in conjunction with multi-wall carbon nanotubes as a potential tumor treatment. Biomed Mater. 2011; 6(1):011002. DOI: 10.1088/1748-6041/6/1/011002. View