BMP Signaling in Mesenchymal Stem Cell Differentiation and Bone Formation

Overview

Journal J Biomed Sci Eng

Date 2016 Jan 29

PMID 26819651

Citations 139

Authors

Maureen Beederman

Joseph D Lamplot

Guoxin Nan

Jinhua Wang

Xing Liu

Liangjun Yin

Ruidong Li

Wei Shui

Hongyu Zhang

Stephanie H Kim

Wenwen Zhang

Jiye Zhang

Yuhan Kong

Sahitya Denduluri

Mary Rose Rogers

Abdullah Pratt

Rex C Haydon

Hue H Luu

Jovito Angeles

Lewis L Shi

Tong-Chuan He

Affiliations

Soon will be listed here.

Abstract

Bone morphogenetic proteins (BMPs) are members of the TGF- superfamily and have diverse functions during development and organogenesis. BMPs play a major role in skeletal development and bone formation, and disruptions in BMP signaling cause a variety of skeletal and extraskeletal anomalies. Several knockout models have provided insight into the mechanisms responsible for these phenotypes. Proper bone formation requires the differentiation of osteoblasts from mesenchymal stem cell (MSC) precursors, a process mediated in part by BMP signaling. Multiple BMPs, including BMP2, BMP6, BMP7 and BMP9, promote osteoblastic differentiation of MSCs both and . BMP9 is one of the most osteogenic BMPs yet is a poorly characterized member of the BMP family. Several studies demonstrate that the mechanisms controlling BMP9-mediated osteogenesis differ from other osteogenic BMPs, but little is known about these specific mechanisms. Several pathways critical to BMP9-mediated osteogenesis are also important in the differentiation of other cell lineages, including adipocytes and chondrocytes. BMP9 has also demonstrated translational promise in spinal fusion and bone fracture repair. This review will summarize our current knowledge of BMP-mediated osteogenesis, with a focus on BMP9, by presenting recently completed work which may help us to further elucidate these pathways.

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