Early Nasogastric Tube Feeding in Optimising Treatment for Hyperemesis Gravidarum: the MOTHER Randomised Controlled Trial (Maternal and Offspring Outcomes After Treatment of HyperEmesis by Refeeding)

Overview

Journal BMC Pregnancy Childbirth

Publisher Biomed Central

Specialty Gynecology & Obstetrics

Date 2016 Jan 29

PMID 26819104

Citations 9

Authors

Iris J Grooten

Ben W Mol

Joris A M van der Post

Carrie Ris-Stalpers

Marjolein Kok

Joke M J Bais

Caroline J Bax

Johannes J Duvekot

Henk A Bremer

Martina M Porath

Wieteke M Heidema

Kitty W M Bloemenkamp

Hubertina C J Scheepers

Maureen T M Franssen

Martijn A Oudijk

Tessa J Roseboom

Rebecca C Painter

Affiliations

Soon will be listed here.

Abstract

Background: Hyperemesis gravidarum (HG), or intractable vomiting during pregnancy, is the single most frequent cause of hospital admission in early pregnancy. HG has a major impact on maternal quality of life and has repeatedly been associated with poor pregnancy outcome such as low birth weight. Currently, women with HG are admitted to hospital for intravenous fluid replacement, without receiving specific nutritional attention. Nasogastric tube feeding is sometimes used as last resort treatment. At present no randomised trials on dietary or rehydration interventions have been performed. Small observational studies indicate that enteral tube feeding may have the ability to effectively treat dehydration and malnutrition and alleviate nausea and vomiting symptoms. We aim to evaluate the effectiveness of early enteral tube feeding in addition to standard care on nausea and vomiting symptoms and pregnancy outcomes in HG patients.

Methods/design: The MOTHER trial is a multicentre open label randomised controlled trial ( www.studies-obsgyn.nl/mother ). Women ≥ 18 years hospitalised for HG between 5 + 0 and 19 + 6 weeks gestation are eligible for participation. After informed consent participants are randomly allocated to standard care with intravenous rehydration or early enteral tube feeding in addition to standard care. All women keep a weekly diary to record symptoms and dietary intake until 20 weeks gestation. The primary outcome will be neonatal birth weight. Secondary outcomes will be the 24-h Pregnancy Unique Quantification of Emesis and nausea score (PUQE-24), maternal weight gain, dietary intake, duration of hospital stay, number of readmissions, quality of life and side-effects. Also gestational age at birth, placental weight, umbilical cord plasma lipid concentration and neonatal morbidity will be evaluated. Analysis will be according to the intention to treat principle.

Discussion: With this trial we aim to clarify whether early enteral tube feeding is more effective in treating HG than intravenous rehydration alone and improves pregnancy outcome.

Trial Registration:

Trial Registration Number: NTR4197 . Date of registration: October 2(nd) 2013.

Citing Articles

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Recurrence, postponing pregnancy, and termination rates after hyperemesis gravidarum: Follow up of the MOTHER study.

Nijsten K, Dean C, van der Minnen L, Bais J, Ris-Stalpers C, van Eekelen R Acta Obstet Gynecol Scand. 2021; 100(9):1636-1643.

PMID: 34033123 PMC: 8457209. DOI: 10.1111/aogs.14197.

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