Serotonin Neurons in the Dorsal Raphe Nucleus Encode Reward Signals

Overview

Journal Nat Commun

Specialty Biology

Date 2016 Jan 29

PMID 26818705

Citations 185

Authors

Yi Li

Weixin Zhong

Daqing Wang

Qiru Feng

Zhixiang Liu

Jingfeng Zhou

Chunying Jia

Fei Hu

Jiawei Zeng

Qingchun Guo

Ling Fu

Minmin Luo

Affiliations

Soon will be listed here.

Abstract

The dorsal raphe nucleus (DRN) is involved in organizing reward-related behaviours; however, it remains unclear how genetically defined neurons in the DRN of a freely behaving animal respond to various natural rewards. Here we addressed this question using fibre photometry and single-unit recording from serotonin (5-HT) neurons and GABA neurons in the DRN of behaving mice. Rewards including sucrose, food, sex and social interaction rapidly activate 5-HT neurons, but aversive stimuli including quinine and footshock do not. Both expected and unexpected rewards activate 5-HT neurons. After mice learn to wait for sucrose delivery, most 5-HT neurons fire tonically during waiting and then phasically on reward acquisition. Finally, GABA neurons are activated by aversive stimuli but inhibited when mice seek rewards. Thus, DRN 5-HT neurons positively encode a wide range of reward signals during anticipatory and consummatory phases of reward responses. Moreover, GABA neurons play a complementary role in reward processing.

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