Cytomegalovirus in Inflammatory Bowel Disease: A Systematic Review

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2016 Jan 27

PMID 26811669

Citations 31

Authors

Tessa E H Romkens

Geert J Bulte

Loes H C Nissen

Joost P H Drenth

Affiliations

Soon will be listed here.

Abstract

Aim: To identify definitions of cytomegalovirus (CMV) infection and intestinal disease, in inflammatory bowel disease (IBD), to determine the prevalence associated with these definitions.

Methods: We conducted a systematic review and interrogated PubMed, EMBASE and Cochrane for literature on prevalence and diagnostics of CMV infection and intestinal disease in IBD patients. As medical headings we used "cytomegalovirus" OR "CMV" OR "cytomegalo virus" AND "inflammatory bowel disease" OR "IBD" OR "ulcerative colitis" OR "colitis ulcerosa" OR "Crohn's disease". Both MeSH-terms and free searches were performed. We included all types of English-language (clinical) trials concerning diagnostics and prevalence of CMV in IBD.

Results: The search strategy identified 924 citations, and 52 articles were eligible for inclusion. We identified 21 different definitions for CMV infection, 8 definitions for CMV intestinal disease and 3 definitions for CMV reactivation. Prevalence numbers depend on used definition, studied population and region. The highest prevalence for CMV infection was found when using positive serum PCR as a definition, whereas for CMV intestinal disease this applies to the use of tissue PCR > 10 copies/mg tissue. Most patients with CMV infection and intestinal disease had steroid refractory disease and came from East Asia.

Conclusion: We detected multiple different definitions used for CMV infection and intestinal disease in IBD patients, which has an effect on prevalence numbers and eventually on outcome in different trials.

Citing Articles

A diagnostic dilemma: cytomegalovirus colitis as an uncommon comorbidity in inflammatory bowel disease: a case report.

Alhalabi M, Alziadan S Virol J. 2024; 21(1):188.

PMID: 39152468 PMC: 11330031. DOI: 10.1186/s12985-024-02467-y.

Diagnostic Utility of Cytomegalovirus (CMV) DNA Quantitation in Ulcerative Colitis.

Esen S, Saglik I, Dolar E, Cesur S, Ugras N, Agca H Viruses. 2024; 16(5).

PMID: 38793573 PMC: 11125958. DOI: 10.3390/v16050691.

Cytomegalovirus Infection in Adult Patients with Inflammatory Bowel Disease: A Literature Review.

Momayaz Sanat Z, Siami Z, Alatab S, Vahedi H, Fanni Z Arch Iran Med. 2024; 27(5):277-286.

PMID: 38690795 PMC: 11097322. DOI: 10.34172/aim.2024.40.

Adequate antiviral treatment lowers overall complications of cytomegalovirus colitis among inpatients with inflammatory bowel diseases.

Hsieh C, Wu R, Kuo C, Yeh P, Yeh Y, Chen C BMC Infect Dis. 2024; 24(1):443.

PMID: 38671346 PMC: 11046852. DOI: 10.1186/s12879-024-09317-w.

Prevalence and Risk Factors of Cytomegalovirus Colitis in Inflammatory Bowel Disease Patients in Riyadh, Saudi Arabia: A Tertiary Center Experience.

Alotaibi Y, Allehibi A, Almtawa A, Alotaibi N, Alghamdi A, Alrajhi S Saudi J Med Med Sci. 2023; 11(4):305-313.

PMID: 37970458 PMC: 10634466. DOI: 10.4103/sjmms.sjmms_175_23.

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