Leuprolide Acetate Induces Structural and Functional Recovery of Injured Spinal Cord in Rats

Overview

Journal Neural Regen Res

Date 2016 Jan 26

PMID 26807118

Citations 8

Authors

Carmen Diaz Galindo

Beatriz Gomez-Gonzalez

Eva Salinas

Denisse Calderon-Vallejo

Irma Hernandez-Jasso

Eduardo Bautista

J Luis Quintanar

Affiliations

Soon will be listed here.

Abstract

Gonadotropin-releasing hormone (GnRH) and its synthetic analog leuprolide acetate, a GnRH agonist, have neurotrophic properties. This study was designed to determine whether administration of leuprolide acetate can improve locomotor behavior, gait, micturition reflex, spinal cord morphology and the amount of microglia in the lesion epicenter after spinal cord injury in rats. Rats with spinal cord compression injury were administered leuprolide acetate or saline solution for 5 weeks. At the 5(th) week, leuprolide acetate-treated rats showed locomotor activity recovery by 38%, had improvement in kinematic gait and exhibited voiding reflex recovery by 60%, as compared with the 1(st) week. By contrast, saline solution-treated rats showed locomotor activity recovery only by 7%, but voiding reflex did not recover. More importantly, leuprolide acetate treatment reduced microglial immunological reaction and induced a trend towards greater area of white and gray matter in the spinal cord. Therefore, leuprolide acetate has great potential to repair spinal cord injury.

Citing Articles

SPATIAL MEMORY RECOVERY IN AGED MALE RATS TREATED WITH LEUPROLIDE ACETATE, A GNRH AGONIST.

Macedo-Mendoza M, Calderon-Vallejo D, Gonzalez-Torres M, Martinez-Martinez A, Gasca-Martinez D, Orta Salazar E Acta Endocrinol (Buchar). 2025; 20(2):127-135.

PMID: 39845751 PMC: 11750219. DOI: 10.4183/aeb.2024.127.

Neurotrophic and synaptic effects of GnRH and/or GH upon motor function after spinal cord injury in rats.

Martinez-Moreno C, Calderon-Vallejo D, Diaz-Galindo C, Hernandez-Jasso I, Olivares-Hernandez J, Avila-Mendoza J Sci Rep. 2024; 14(1):26420.

PMID: 39488642 PMC: 11531546. DOI: 10.1038/s41598-024-78073-3.

Neurological recovery in rats with portocaval anastomosis-induced hepatic encephalopathy treated with leuprolide acetate, a GnRH agonist.

Gutierrez-Esparza B, Gonzalez-Torres M, Quintanar-Stephano A, Quintanar J Metab Brain Dis. 2024; 39(7):1447-1458.

PMID: 39177865 DOI: 10.1007/s11011-024-01413-9.

Gonadotropin-releasing hormone and growth hormone act as anti-inflammatory factors improving sensory recovery in female rats with thoracic spinal cord injury.

Martinez-Moreno C, Calderon-Vallejo D, Diaz-Galindo C, Hernandez-Jasso I, Olivares-Hernandez J, Avila-Mendoza J Front Neurosci. 2023; 17:1164044.

PMID: 37360158 PMC: 10288327. DOI: 10.3389/fnins.2023.1164044.

Effects of Extracorporeal Shockwave Therapy on Functional Recovery and Circulating miR-375 and miR-382-5p after Subacute and Chronic Spinal Cord Contusion Injury in Rats.

Ashmwe M, Posa K, Ruhrnossl A, Heinzel J, Heimel P, Mock M Biomedicines. 2022; 10(7).

PMID: 35884935 PMC: 9313454. DOI: 10.3390/biomedicines10071630.

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