Serum Uric Acid and AKI: is It Time?

Overview

Journal Clin Kidney J

Publisher Oxford University Press

Specialty Nephrology

Date 2016 Jan 23

PMID 26798460

Citations 3

Authors

Manish Kaushik

Jason Chon Jun Choo

Affiliations

Soon will be listed here.

Abstract

Acute kidney injury (AKI) is a well-recognized complication in hospitalized patients, with associated mortality and morbidity. Studies that aim to prevent or reverse AKI using pharmacological and interventional therapies in clinical practice have been disappointing. Work is continuing to identify potentially modifiable risk factors for AKI. Early identification and modification of these risk factors may help prevent or favorably influence the outcome of AKI. The role of uric acid as a potential risk factor is being revisited in chronic kidney disease and AKI. Apart from the established crystal precipitation with profound hyperuricemia, various non-crystal mechanisms have also been proposed in the pathogenesis of AKI. The association of serum uric acid levels with the development of AKI has been reported in various clinical settings. Together, the results of these studies highlight hyperuricemia as a potential risk factor of AKI and the need for further work on this subject.

Citing Articles

Association between hyperuricemia and acute kidney injury in critically ill patients with sepsis.

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Development of an acute kidney injury risk prediction model for patients undergoing extracorporeal membrane oxygenation.

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Benefits of D-005, a lipid extract from Acrocomia crispa fruits, in the prevention of acute kidney njury induced by nephrotoxicity in rats.

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