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The Conserved Molecular Machinery in DNA Mismatch Repair Enzyme Structures

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Publisher Elsevier
Date 2016 Jan 23
PMID 26796427
Citations 43
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Abstract

The machinery of DNA mismatch repair enzymes is highly conserved in evolution. The process is initiated by recognition of a DNA mismatch, and validated by ATP and the presence of a processivity clamp or a methylation mark. Several events in MMR promote conformational changes that lead to progression of the repair process. Here we discuss functional conformational changes in the MMR proteins and we compare the enzymes to paralogs in other systems.

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