Adeno-associated Virus (AAV) Vectors in Cancer Gene Therapy

Overview

Journal J Control Release

Specialty Pharmacology

Date 2016 Jan 23

PMID 26796040

Citations 110

Authors

Jorge L Santiago-Ortiz

David V Schaffer

Affiliations

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Abstract

Gene delivery vectors based on adeno-associated virus (AAV) have been utilized in a large number of gene therapy clinical trials, which have demonstrated their strong safety profile and increasingly their therapeutic efficacy for treating monogenic diseases. For cancer applications, AAV vectors have been harnessed for delivery of an extensive repertoire of transgenes to preclinical models and, more recently, clinical trials involving certain cancers. This review describes the applications of AAV vectors to cancer models and presents developments in vector engineering and payload design aimed at tailoring AAV vectors for transduction and treatment of cancer cells. We also discuss the current status of AAV clinical development in oncology and future directions for AAV in this field.

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