Sex Differences in Response to Hepatitis B Infection Among Patients Receiving Chronic Dialysis Treatment

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1977 Jun 1

PMID 267950

Citations 15

Authors

W T London

J S Drew

Affiliations

Soon will be listed here.

Abstract

Patients undergoing treatment at a community-based renal dialysis clinic were monitored monthly for hepatitis B surface antigen (HBsAg) and antibody to HBsAg (anti-HBs). Of 160 patients who began treatment HBsAg(-)/anti-HBs(-), 77 subsequently became HBsAg(+). Once HBsAg(+), males were more likely to remain HBsAg(+) indefinitely, whereas females were more likely to convert to HBsAg(-) and develop anti-HBs. This was not due to a sex difference in exposure to hepatitis B virus because only patients who became infected while undergoing treatment were included in the analysis. These data are clear evidence of a sex difference in response to hepatitis B virus, which may partially explain the greater incidence of several chronic liver diseases, including primary hepatocellular carcinoma, in males.

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