Bariatric Surgery for Morbid Obesity: Tehran Obesity Treatment Study (TOTS) Rationale and Study Design

Overview

Journal JMIR Res Protoc

Publisher JMIR Publications

Specialty General Medicine

Date 2016 Jan 22

PMID 26792554

Citations 31

Authors

Maryam Barzin

Farhad Hosseinpanah

Mohammad Ali Motamedi

Parvin Shapoori

Peyman Arian

Maryam Alsadat Daneshpour

Golale Asghari

Ahmad Teymoornejad

Ali Eslamifar

Davood Khalili

Behzad Jodeiri

Shahram Alamdari

Fereidoun Azizi

Alireza Khalaj

Affiliations

Soon will be listed here.

Abstract

Background: Obesity is a major health concern in the Middle East and worldwide. It is among the leading causes of morbidity, mortality, health care utilization, and costs. With bariatric surgery proving to be a more effective treatment option for overweight and obesity, the need for systematic assessment of different procedures and their outcomes becomes necessary. These procedures have not yet been described in detail in our region.

Objective: We aim to undertake a prospective study evaluating and comparing several surgical bariatric procedures in an Iranian population of morbid obese patients presenting to a specialized bariatric center.

Methods: In order to facilitate and accelerate understanding of obesity and its complications, the Tehran Obesity Treatment Study (TOTS) was planned and developed. This study is a longitudinal prospective cohort study in consecutive patients undergoing bariatric surgery. TOTS investigators use standardized definitions, high-fidelity data collection system, and validated instruments to gather data preoperatively, at the time of surgery, postoperatively, and in longer-term follow-up.

Results: This study has recruited 1050 participants as of September 2015 and is ongoing.

Conclusions: This study will ensure creation of high-level evidence to enable clinicians to make meaningful evidence-based decisions for patient evaluation, selection for surgery, and follow-up care.

Citing Articles

Legacy of the Tehran Obesity Treatment Study: Findings from 10 Years Bariatric Surgery Survey.

Abiri B, Heidari Almasi M, Hosseinpanah F, Molavizadeh D, Khalaj A, Mahdavi M Int J Endocrinol Metab. 2025; 22(4):e151608.

PMID: 40071051 PMC: 11892694. DOI: 10.5812/ijem-151608.

Safety and efficacy of sleeve gastrectomy in non-diabetic individuals with class I vs. class II obesity: a matched controlled experiment from Tehran Obesity Treatment Study (TOTS).

Heidari Almasi M, Barzin M, Khalaj A, Mahdavi M, Valizadeh M, Hosseinpanah F Surg Endosc. 2024; 38(11):6625-6636.

PMID: 39289225 DOI: 10.1007/s00464-024-11240-9.

Major dietary patterns and their associations with total weight loss and weight loss composition 2-4 years after sleeve gastrectomy.

Moslehi N, Kamali Z, Barzin M, Khalaj A, Mirmiran P Eur J Med Res. 2024; 29(1):417.

PMID: 39138509 PMC: 11321093. DOI: 10.1186/s40001-024-02009-w.

Development and validation of a healthy diet and physical activity tool based on health action process approach among patients undergone bariatric surgery.

Maghsoodlo M, Shakibazadeh E, Mokhtary Z, Barzin M, Yaseri M, Salimi Y J Diabetes Metab Disord. 2024; 23(1):1007-1015.

PMID: 38932896 PMC: 11196544. DOI: 10.1007/s40200-023-01380-5.

LAPAROSCOPIC SLEEVE GASTRECTOMY VERSUS LAPAROSCOPIC ROUX-EN-Y GASTRIC BYPASS FOR WEIGHT LOSS IN OBESE PATIENTS: WHICH IS MORE EFFECTIVE? A SYSTEMATIC REVIEW AND META-ANALYSIS.

Garcia-Honores L, Caballero-Alvarado J, Bustamante-Cabrejos A, Lozano-Peralta K, Zavaleta-Corvera C Arq Bras Cir Dig. 2023; 36:e1782.

PMID: 38088727 PMC: 10712920. DOI: 10.1590/0102-672020230064e1782.

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