Neural Changes Developed During the Extinction of Cocaine Self-Administration Behavior

Overview

Journal Pharmaceuticals (Basel)

Publisher MDPI

Specialty Chemistry

Date 2016 Jan 22

PMID 26791639

Authors

Alejandro Higuera-Matas

Miguel Miguens

Nuria Del Olmo

Carmen Garcia-Lecumberri

Emilio Ambrosio

Affiliations

Soon will be listed here.

Abstract

The high rate of recidivism in cocaine addiction after prolonged periods of abstinence poses a significant problem for the effective treatment of this condition. Moreover, the neurobiological basis of this relapse phenomenon remains poorly understood. In this review, we will discuss the evidence currently available regarding the neurobiological changes during the extinction of cocaine self-administration. Specifically, we will focus on alterations in the dopaminergic, opioidergic, glutamatergic, cholinergic, serotoninergic and CRF systems described in self-administration experiments and extinction studies after chronic cocaine administration. We will also discuss the differences related to contingent versus non-contingent cocaine administration, which highlights the importance of environmental cues on drug effects and extinction. The findings discussed in this review may aid the development of more effective therapeutic approaches to treat cocaine relapse.

References

Crespo J, Manzanares J, Oliva J, Corchero J, Palomo T, Ambrosio E . Extinction of cocaine self-administration produces a differential time-related regulation of proenkephalin gene expression in rat brain. Neuropsychopharmacology. 2001; 25(2):185-94. DOI: 10.1016/S0893-133X(01)00221-4. View

Ahmed S . The science of making drug-addicted animals. Neuroscience. 2011; 211:107-25. DOI: 10.1016/j.neuroscience.2011.08.014. View

Robinson T, Berridge K . Review. The incentive sensitization theory of addiction: some current issues. Philos Trans R Soc Lond B Biol Sci. 2008; 363(1507):3137-46. PMC: 2607325. DOI: 10.1098/rstb.2008.0093. View

Malenka R, Bear M . LTP and LTD: an embarrassment of riches. Neuron. 2004; 44(1):5-21. DOI: 10.1016/j.neuron.2004.09.012. View

Haney M . Self-administration of cocaine, cannabis and heroin in the human laboratory: benefits and pitfalls. Addict Biol. 2008; 14(1):9-21. PMC: 2743289. DOI: 10.1111/j.1369-1600.2008.00121.x. View

Calabresi P, Picconi B, Tozzi A, Di Filippo M . Dopamine-mediated regulation of corticostriatal synaptic plasticity. Trends Neurosci. 2007; 30(5):211-9. DOI: 10.1016/j.tins.2007.03.001. View

Filip M, Alenina N, Bader M, Przegalinski E . Behavioral evidence for the significance of serotoninergic (5-HT) receptors in cocaine addiction. Addict Biol. 2010; 15(3):227-49. DOI: 10.1111/j.1369-1600.2010.00214.x. View

Epstein D, Preston K, Stewart J, Shaham Y . Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure. Psychopharmacology (Berl). 2006; 189(1):1-16. PMC: 1618790. DOI: 10.1007/s00213-006-0529-6. View

Maurice T, Martin-Fardon R, Romieu P, Matsumoto R . Sigma(1) (sigma(1)) receptor antagonists represent a new strategy against cocaine addiction and toxicity. Neurosci Biobehav Rev. 2002; 26(4):499-527. DOI: 10.1016/s0149-7634(02)00017-9. View

10.

Koob G, Moal M . Addiction and the brain antireward system. Annu Rev Psychol. 2007; 59:29-53. DOI: 10.1146/annurev.psych.59.103006.093548. View

11.

Tanda G, Ebbs A, Kopajtic T, Elias L, Campbell B, Newman A . Effects of muscarinic M1 receptor blockade on cocaine-induced elevations of brain dopamine levels and locomotor behavior in rats. J Pharmacol Exp Ther. 2007; 321(1):334-44. DOI: 10.1124/jpet.106.118067. View

12.

Thomsen M, Conn P, Lindsley C, Wess J, Boon J, Fulton B . Attenuation of cocaine's reinforcing and discriminative stimulus effects via muscarinic M1 acetylcholine receptor stimulation. J Pharmacol Exp Ther. 2009; 332(3):959-69. PMC: 2835434. DOI: 10.1124/jpet.109.162057. View

13.

Crespo J, Oliva J, Ghasemzadeh M, Kalivas P, Ambrosio E . Neuroadaptive changes in NMDAR1 gene expression after extinction of cocaine self-administration. Ann N Y Acad Sci. 2002; 965:78-91. DOI: 10.1111/j.1749-6632.2002.tb04153.x. View

14.

Karila L, Reynaud M, Aubin H, Rolland B, Guardia D, Cottencin O . Pharmacological treatments for cocaine dependence: is there something new?. Curr Pharm Des. 2011; 17(14):1359-68. DOI: 10.2174/138161211796150873. View

15.

Ahmed S . Validation crisis in animal models of drug addiction: beyond non-disordered drug use toward drug addiction. Neurosci Biobehav Rev. 2010; 35(2):172-84. DOI: 10.1016/j.neubiorev.2010.04.005. View

16.

Nader M, Daunais J, Moore T, Nader S, Moore R, Smith H . Effects of cocaine self-administration on striatal dopamine systems in rhesus monkeys: initial and chronic exposure. Neuropsychopharmacology. 2002; 27(1):35-46. DOI: 10.1016/S0893-133X(01)00427-4. View

17.

Schmidt E, Sutton M, Schad C, Karanian D, Brodkin E, Self D . Extinction training regulates tyrosine hydroxylase during withdrawal from cocaine self-administration. J Neurosci. 2001; 21(7):RC137. PMC: 6762412. View

18.

Edwards S, Koob G . Neurobiology of dysregulated motivational systems in drug addiction. Future Neurol. 2010; 5(3):393-401. PMC: 2886284. DOI: 10.2217/fnl.10.14. View

19.

Ikegami A, Duvauchelle C . Dopamine mechanisms and cocaine reward. Int Rev Neurobiol. 2004; 62:45-94. DOI: 10.1016/S0074-7742(04)62002-2. View

20.

Sutton M, Schmidt E, Choi K, Schad C, Whisler K, Simmons D . Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour. Nature. 2003; 421(6918):70-5. DOI: 10.1038/nature01249. View