Baroreflex Dysfunction in Chronic Kidney Disease

Overview

Journal World J Nephrol

Publisher Baishideng Publishing Group

Specialty Nephrology

Date 2016 Jan 21

PMID 26788464

Citations 9

Authors

Manpreet Kaur

Dinu S Chandran

Ashok Kumar Jaryal

Dipankar Bhowmik

Sanjay Kumar Agarwal

Kishore Kumar Deepak

Affiliations

Soon will be listed here.

Abstract

Chronic kidney disease (CKD) patients have high cardiovascular mortality and morbidity. The presence of traditional and CKD related risk factors results in exaggerated vascular calcification in these patients. Vascular calcification is associated with reduced large arterial compliance and thus impaired baroreflex sensitivity (BRS) resulting in augmented blood pressure (BP) variability and hampered BP regulation. Baroreflex plays a vital role in short term regulation of BP. This review discusses the normal baroreflex physiology, methods to assess baroreflex function, its determinants along with the prognostic significance of assessing BRS in CKD patients, available literature on BRS in CKD patients and the probable patho-physiology of baroreflex dysfunction in CKD.

Citing Articles

Baroreflex Sensitivity Assessment Using the Sequence Method with Delayed Signals in End-Stage Renal Disease Patients.

Martinez-Alanis M, Calderon-Juarez M, Martinez-Garcia P, Gonzalez Gomez G, Infante O, Perez-Grovas H Sensors (Basel). 2023; 23(1).

PMID: 36616859 PMC: 9823877. DOI: 10.3390/s23010260.

High-Volume Hemodiafiltration and Cool Hemodialysis Have a Beneficial Effect on Intradialytic Hemodynamics: A Randomized Cross-Over Trial of Four Intermittent Dialysis Strategies.

Rootjes P, Chaara S, de Roij van Zuijdewijn C, Nube M, Wijngaarden G, Grooteman M Kidney Int Rep. 2022; 7(9):1980-1990.

PMID: 36090495 PMC: 9459077. DOI: 10.1016/j.ekir.2022.06.021.

Naringin and Trimetazidine Improve Baroreflex Sensitivity and Nucleus Tractus Solitarius Electrical Activity in Renal Ischemia-Reperfusion Injury.

Amini N, Sarkaki A, Dianat M, Mard S, Ahangarpour A, Badavi M Arq Bras Cardiol. 2021; 117(2):290-297.

PMID: 34495221 PMC: 8395798. DOI: 10.36660/abc.20200121.

Increased fibroblast growth factor-21 in chronic kidney disease is a trade-off between survival benefit and blood pressure dysregulation.

Nakano T, Shiizaki K, Miura Y, Matsui M, Kosaki K, Mori S Sci Rep. 2019; 9(1):19247.

PMID: 31848393 PMC: 6917750. DOI: 10.1038/s41598-019-55643-4.

Arterial Stiffness in the Heart Disease of CKD.

Zanoli L, Lentini P, Briet M, Castellino P, House A, London G J Am Soc Nephrol. 2019; 30(6):918-928.

PMID: 31040188 PMC: 6551785. DOI: 10.1681/ASN.2019020117.

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