Radiation-induced Pulmonary Injury Accelerated Pulmonary Metastasis in a Mouse Model of Breast Cancer

Overview

Journal Oncol Lett

Specialty Oncology

Date 2016 Jan 21

PMID 26788178

Citations 10

Authors

Hong-Yun Gong

Wei-Guo Hu

Qin-Yong Hu

Xiang-Pan Li

Qi-Bin Song

Affiliations

Soon will be listed here.

Abstract

The aim of the present study was to investigate the acceleration of pulmonary metastasis due to pulmonary injury caused by radiation treatment in a mouse model of breast cancer, in addition to determining the associated mechanism. The passive metastatic breast cancer model was used in radiation-treated BALB/c mice. In total, 24 mice were randomly separated into two groups, with 12 mice per group, and the groups were treated with or without pulmonary radiation. The survival time and variation of the weights of the lungs, spleen and liver were recorded. Lung metastasis was also evaluated, and chemokine (C-X-C motif) ligand 12 (CXCL12)/chemokine (C-X-C motif) receptor 4 (CXCR4) expression was determined. The results revealed that the group with radiation-induced pulmonary injury exhibited an increased incidence of pulmonary metastasis and shorter survival time compared with the mice without pulmonary radiation. The radiation-treated group possessed an increased number of metastatic nodules in the lungs, but metastasis was not evident in the liver and spleen. The CXCL12/CXCR4 axis was markedly expressed and the expression was significantly increased subsequent to radiation compared with the expression in normal lung tissues. The present study demonstrated that radiation-induced pulmonary injury may accelerate metastatic tumor growth and decrease the overall survival rate of the mice following injection of tumor cells. Tumor localization and growth may have been favored by metastatic conditioning in the lung subsequent to radiotherapy. The CXCL12/CXCR4 axis may affect key elements in the multistep process of metastasis induced by radiation injury.

Citing Articles

Identification of Key Genes and Pathways Associated With Irradiation in Breast Cancer Tissue and Breast Cancer Cell Lines.

Zhu C, Ge C, He J, Zhang X, Feng G, Fan S Dose Response. 2020; 18(2):1559325820931252.

PMID: 32684870 PMC: 7346585. DOI: 10.1177/1559325820931252.

Radioprotective effect of diethylcarbamazine on radiation-induced acute lung injury and oxidative stress in mice.

Farzipour S, Talebpour Amiri F, Mihandoust E, Shaki F, Noaparast Z, Ghasemi A J Bioenerg Biomembr. 2019; 52(1):39-46.

PMID: 31853753 DOI: 10.1007/s10863-019-09820-9.

Effects of radiation on the metastatic process.

Sundahl N, Duprez F, Ost P, De Neve W, Mareel M Mol Med. 2018; 24(1):16.

PMID: 30134800 PMC: 6016893. DOI: 10.1186/s10020-018-0015-8.

Limited fibrosis accompanies triple-negative breast cancer metastasis in multiple model systems and is not a preventive target.

Brooks D, Zimmer A, Wakefield L, Lyle L, Difilippantonio S, Tucci F Oncotarget. 2018; 9(34):23462-23481.

PMID: 29805748 PMC: 5955109. DOI: 10.18632/oncotarget.25231.

Breast cancer lung metastasis: Molecular biology and therapeutic implications.

Jin L, Han B, Siegel E, Cui Y, Giuliano A, Cui X Cancer Biol Ther. 2018; 19(10):858-868.

PMID: 29580128 PMC: 6300341. DOI: 10.1080/15384047.2018.1456599.

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