Notch-Mediated Cell Adhesion

Overview

Journal Biology (Basel)

Publisher MDPI

Specialty Biology

Date 2016 Jan 20

PMID 26784245

Citations 10

Authors

Akihiko Murata

Shin-Ichi Hayashi

Affiliations

Soon will be listed here.

Abstract

Notch family members are generally recognized as signaling molecules that control various cellular responses in metazoan organisms. Early fly studies and our mammalian studies demonstrated that Notch family members are also cell adhesion molecules; however, information on the physiological roles of this function and its origin is limited. In this review, we discuss the potential present and ancestral roles of Notch-mediated cell adhesion in order to explore its origin and the initial roles of Notch family members dating back to metazoan evolution. We hypothesize that Notch family members may have initially emerged as cell adhesion molecules in order to mediate multicellularity in the last common ancestor of metazoan organisms.

Citing Articles

Notch Signaling: An Emerging Paradigm in the Pathogenesis of Reproductive Disorders and Diverse Pathological Conditions.

Parambath S, Selvraj N, Venugopal P, Aradhya R Int J Mol Sci. 2024; 25(10).

PMID: 38791461 PMC: 11121885. DOI: 10.3390/ijms25105423.

Evolution and Function of the Notch Signaling Pathway: An Invertebrate Perspective.

Lv Y, Pang X, Cao Z, Song C, Liu B, Wu W Int J Mol Sci. 2024; 25(6).

PMID: 38542296 PMC: 10970066. DOI: 10.3390/ijms25063322.

A Cellular Potts Model of the interplay of synchronization and aggregation.

Una R, Glimm T PeerJ. 2024; 12:e16974.

PMID: 38435996 PMC: 10909357. DOI: 10.7717/peerj.16974.

A Comprehensive Bioinformatic Analysis of NOTCH Pathway Involvement in Stomach Adenocarcinoma.

Xue D, Li D, Dou C, Li J Dis Markers. 2021; 2021:4739868.

PMID: 34925644 PMC: 8674080. DOI: 10.1155/2021/4739868.

MAML1: a coregulator that alters endometrial epithelial cell adhesive capacity.

Zafir S, Zhou W, Menkhorst E, Santos L, Dimitriadis E Fertil Res Pract. 2021; 7(1):8.

PMID: 33773601 PMC: 8004388. DOI: 10.1186/s40738-021-00100-y.

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