Marine Isonitriles and Their Related Compounds

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2016 Jan 20

PMID 26784208

Citations 24

Authors

Jens Emsermann

Ulrich Kauhl

Till Opatz

Affiliations

Soon will be listed here.

Abstract

Marine isonitriles represent the largest group of natural products carrying the remarkable isocyanide moiety. Together with marine isothiocyanates and formamides, which originate from the same biosynthetic pathways, they offer diverse biological activities and in spite of their exotic nature they may constitute potential lead structures for pharmaceutical development. Among other biological activities, several marine isonitriles show antimalarial, antitubercular, antifouling and antiplasmodial effects. In contrast to terrestrial isonitriles, which are mostly derived from α-amino acids, the vast majority of marine representatives are of terpenoid origin. An overview of all known marine isonitriles and their congeners will be given and their biological and chemical aspects will be discussed.

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