Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes

Overview

Journal Dis Markers

Publisher Wiley

Specialty Biochemistry

Date 2016 Jan 20

PMID 26783378

Citations 22

Authors

Ana Carolina B Stefanini

Bianca Rodrigues da Cunha

Tiago Henrique

Eloiza H Tajara

Affiliations

Soon will be listed here.

Abstract

Human kallikrein-related peptidases (KLKs) are a subgroup of serine proteases that participate in proteolytic pathways and control protein levels in normal physiology as well as in several pathological conditions. Their complex network of stimulatory and inhibitory interactions may induce inflammatory and immune responses and contribute to the neoplastic phenotype through the regulation of several cellular processes, such as proliferation, survival, migration, and invasion. This family of proteases, which includes one of the most useful cancer biomarkers, kallikrein-related peptidase 3 or PSA, also has a protective effect against cancer promoting apoptosis or counteracting angiogenesis and cell proliferation. Therefore, they represent attractive therapeutic targets and may have important applications in clinical oncology. Despite being intensively studied, many gaps in our knowledge on several molecular aspects of KLK functions still exist. This review aims to summarize recent data on their involvement in different processes related to health and disease, in particular those directly or indirectly linked to the neoplastic process.

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