Effects of Age, Experience and Inter-alpha Inhibitor Proteins on Working Memory and Neuronal Plasticity After Neonatal Hypoxia-ischemia

Overview

Journal Behav Brain Res

Specialties Neurology
Psychology
Social Sciences

Date 2016 Jan 19

PMID 26778784

Citations 20

Authors

Cynthia M Gaudet

Yow-Pin Lim

Barbara S Stonestreet

Steven W Threlkeld

Affiliations

Soon will be listed here.

Abstract

Neonatal cerebral hypoxia-ischemia (HI) commonly results in cognitive and sensory impairments. Early behavioral experience has been suggested to improve cognitive and sensory outcomes in children and animal models with perinatal neuropathology. In parallel, we previously showed that treatment with immunomodulator Inter-alpha Inhibitor Proteins (IAIPs) improves cellular and behavioral outcomes in neonatal HI injured rats. The purpose of the current study was to evaluate the influences of early experience and typical maturation in combination with IAIPs treatment on spatial working and reference memory after neonatal HI injury. A second aim was to determine the effects of these variables on hippocampal CA1 neuronal morphology. Subjects were divided into two groups that differed with respect to the time when exposed to eight arm radial water maze testing: Group one was tested as juveniles (early experience, Postnatal day (P) 36-61) and adults (P88-113), and Group two was tested in adulthood only (P88-113; without early experience). Three treatment conditions were included in each experience group (HI+Vehicle, HI+IAIPs, and Sham subjects). Incorrect arm entries (errors) were compared between treatment and experience groups across three error types (reference memory (RM), working memory incorrect (WMI), working memory correct (WMC)). Early experience led to improved working memory performance regardless of treatment. Combining IAIPs intervention with early experience provided a long-term behavioral advantage on the WMI component of the task in HI animals. Anatomically, early experience led to a decrease in the average number of basal dendrites per CA1 pyramidal neuron for IAIP treated subjects and a significant reduction in basal dendritic length in control subjects, highlighting the importance of pruning in typical early life learning. Our results support the hypothesis that early behavioral experience combined with IAIPs improve outcome on a relativity demanding cognitive task, beyond that of a single intervention strategy, and appears to facilitate neuronal plasticity following neonatal brain injury.

Citing Articles

Inter-alpha Inhibitor Proteins Modulate Microvascular Endothelial Components and Cytokines After Exposure to Hypoxia-Ischemia in Neonatal Rats.

Koehn L, Nguyen K, Tucker R, Lim Y, Chen X, Stonestreet B Mol Neurobiol. 2024; 62(4):5057-5072.

PMID: 39505805 DOI: 10.1007/s12035-024-04594-7.

Association between decreased cord blood inter-alpha inhibitor levels and neonatal encephalopathy at birth.

Bitar L, Stonestreet B, Lim Y, Qiu J, Chen X, Mir I Early Hum Dev. 2024; 193:106036.

PMID: 38733833 PMC: 11768766. DOI: 10.1016/j.earlhumdev.2024.106036.

Inter-Alpha Inhibitor Proteins Modify the Microvasculature after Exposure to Hypoxia-Ischemia and Hypoxia in Neonatal Rats.

Girolamo F, Lim Y, Virgintino D, Stonestreet B, Chen X Int J Mol Sci. 2023; 24(7).

PMID: 37047713 PMC: 10094872. DOI: 10.3390/ijms24076743.

Effects of Three Different Doses of Inter-Alpha Inhibitor Proteins on Severe Hypoxia-Ischemia-Related Brain Injury in Neonatal Rats.

Koehn L, Nguyen K, Chen X, Santoso A, Tucker R, Lim Y Int J Mol Sci. 2022; 23(21).

PMID: 36362257 PMC: 9655902. DOI: 10.3390/ijms232113473.

Inter-alpha Inhibitor Proteins Ameliorate Brain Injury and Improve Behavioral Outcomes in a Sex-Dependent Manner After Exposure to Neonatal Hypoxia Ischemia in Newborn and Young Adult Rats.

Chen X, Zhang J, Wu Y, Tucker R, Baird G, Domonoske R Neurotherapeutics. 2022; 19(2):528-549.

PMID: 35290609 PMC: 9226254. DOI: 10.1007/s13311-022-01217-8.

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