Nanotechnology for Delivery of Peptide Nucleic Acids (PNAs)

Overview

Journal J Control Release

Specialty Pharmacology

Date 2016 Jan 19

PMID 26776051

Citations 29

Authors

Anisha Gupta

Raman Bahal

Meera Gupta

Peter M Glazer

W Mark Saltzman

Affiliations

Soon will be listed here.

Abstract

Over the past three decades, peptide nucleic acids have been employed in numerous chemical and biological applications. Peptide nucleic acids possess enormous potential because of their superior biophysical properties, compared to other oligonucleotide chemistries. However, for therapeutic applications, intracellular delivery of peptide nucleic acids remains a challenge. In this review, we summarize the progress that has been made in delivering peptide nucleic acids to intracellular targets. In addition, we emphasize recent nanoparticle-based strategies for efficient delivery of conventional and chemically-modified peptides nucleic acids.

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