MiRNAs Regulation and Its Role As Biomarkers in Endometriosis

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2016 Jan 16

PMID 26771608

Citations 40

Authors

Josep Mari-Alexandre

Dolors Sanchez-Izquierdo

Juan Gilabert-Estelles

Moises Barcelo-Molina

Aitana Braza-Boils

Juan Sandoval

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs (18-22 nt) that function as modulators of gene expression. Since their discovery in 1993 in C. elegans, our knowledge about their biogenesis, function, and mechanism of action has increased enormously, especially in recent years, with the development of deep-sequencing technologies. New biogenesis pathways and sources of miRNAs are changing our concept about these molecules. The study of the miRNA contribution to pathological states is a field of great interest in research. Different groups have reported the implication of miRNAs in pathologies such as cancer, diabetes, cardiovascular, and gynecological diseases. It is also well-known that miRNAs are present in biofluids (plasma, serum, urine, semen, and menstrual blood) and have been proposed as ideal candidates as disease biomarkers. The goal of this review is to highlight the current knowledge in the field of miRNAs with a special emphasis to their role in endometriosis and the newest investigations addressing the use of miRNAs as biomarkers for this gynecological disease.

Citing Articles

The Known, the Unknown and the Future of the Pathophysiology of Endometriosis.

Ochoa Bernal M, Fazleabas A Int J Mol Sci. 2024; 25(11).

PMID: 38892003 PMC: 11172035. DOI: 10.3390/ijms25115815.

Establishment of a neutrophil extracellular trap-related prognostic signature for colorectal cancer liver metastasis and expression validation of CYP4F3.

Tang X, Xu Z, Guan J, Yao J, Tang X, Zhou Z Clin Exp Med. 2024; 24(1):112.

PMID: 38795162 PMC: 11127854. DOI: 10.1007/s10238-024-01378-0.

Circulating microRNAs as Non-Invasive Biomarkers in Endometriosis Diagnosis-A Systematic Review.

Vanhie A, Caron E, Vermeersch E, O D, Tomassetti C, Meuleman C Biomedicines. 2024; 12(4).

PMID: 38672242 PMC: 11048084. DOI: 10.3390/biomedicines12040888.

Association of endometriosis with Sjögren's syndrome: Genetic insights (Review).

Zervou M, Tarlatzis B, Grimbizis G, Spandidos D, Niewold T, Goulielmos G Int J Mol Med. 2024; 53(2).

PMID: 38186322 PMC: 10781419. DOI: 10.3892/ijmm.2024.5344.

miRNA Expression Profiles in Ovarian Endometriosis and Two Types of Ovarian Cancer-Endometriosis-Associated Ovarian Cancer and High-Grade Ovarian Cancer.

Szubert M, Nowak-Gluck A, Domanska-Senderowska D, Szymanska B, Sowa P, Rycerz A Int J Mol Sci. 2023; 24(24).

PMID: 38139300 PMC: 10743418. DOI: 10.3390/ijms242417470.

References

Nnoaham K, Hummelshoj L, Kennedy S, Jenkinson C, Zondervan K . Developing symptom-based predictive models of endometriosis as a clinical screening tool: results from a multicenter study. Fertil Steril. 2012; 98(3):692-701.e5. PMC: 3679490. DOI: 10.1016/j.fertnstert.2012.04.022. View

Eulalio A, Huntzinger E, Izaurralde E . Getting to the root of miRNA-mediated gene silencing. Cell. 2008; 132(1):9-14. DOI: 10.1016/j.cell.2007.12.024. View

Vickers K, Palmisano B, Shoucri B, Shamburek R, Remaley A . MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol. 2011; 13(4):423-33. PMC: 3074610. DOI: 10.1038/ncb2210. View

. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther. 2001; 69(3):89-95. DOI: 10.1067/mcp.2001.113989. View

Burney R, Giudice L . Pathogenesis and pathophysiology of endometriosis. Fertil Steril. 2012; 98(3):511-9. PMC: 3836682. DOI: 10.1016/j.fertnstert.2012.06.029. View

van Bakel H, Nislow C, Blencowe B, Hughes T . Most "dark matter" transcripts are associated with known genes. PLoS Biol. 2010; 8(5):e1000371. PMC: 2872640. DOI: 10.1371/journal.pbio.1000371. View

Stilley J, Birt J, Sharpe-Timms K . Cellular and molecular basis for endometriosis-associated infertility. Cell Tissue Res. 2012; 349(3):849-62. PMC: 3429772. DOI: 10.1007/s00441-011-1309-0. View

Nisolle M, Donnez J . Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities. Fertil Steril. 1997; 68(4):585-96. DOI: 10.1016/s0015-0282(97)00191-x. View

Filigheddu N, Gregnanin I, Porporato P, Surico D, Perego B, Galli L . Differential expression of microRNAs between eutopic and ectopic endometrium in ovarian endometriosis. J Biomed Biotechnol. 2010; 2010:369549. PMC: 2837904. DOI: 10.1155/2010/369549. View

10.

Fabbri M . TLRs as miRNA receptors. Cancer Res. 2012; 72(24):6333-7. DOI: 10.1158/0008-5472.CAN-12-3229. View

11.

Burney R, Hamilton A, Aghajanova L, Vo K, Nezhat C, Lessey B . MicroRNA expression profiling of eutopic secretory endometrium in women with versus without endometriosis. Mol Hum Reprod. 2009; 15(10):625-31. PMC: 2744474. DOI: 10.1093/molehr/gap068. View

12.

Hawkins S, Creighton C, Han D, Zariff A, Anderson M, Gunaratne P . Functional microRNA involved in endometriosis. Mol Endocrinol. 2011; 25(5):821-32. PMC: 3082329. DOI: 10.1210/me.2010-0371. View

13.

Fassbender A, Vodolazkaia A, Saunders P, Lebovic D, Waelkens E, De Moor B . Biomarkers of endometriosis. Fertil Steril. 2013; 99(4):1135-45. DOI: 10.1016/j.fertnstert.2013.01.097. View

14.

Birney E, Stamatoyannopoulos J, Dutta A, Guigo R, Gingeras T, Margulies E . Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 2007; 447(7146):799-816. PMC: 2212820. DOI: 10.1038/nature05874. View

15.

Hacia J, Fan J, Ryder O, Jin L, Edgemon K, Ghandour G . Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays. Nat Genet. 1999; 22(2):164-7. DOI: 10.1038/9674. View

16.

Giudice L, Kao L . Endometriosis. Lancet. 2004; 364(9447):1789-99. DOI: 10.1016/S0140-6736(04)17403-5. View

17.

Neilsen C, Goodall G, Bracken C . IsomiRs--the overlooked repertoire in the dynamic microRNAome. Trends Genet. 2012; 28(11):544-9. DOI: 10.1016/j.tig.2012.07.005. View

18.

Fassbender A, Rahmioglu N, Vitonis A, Vigano P, Giudice L, DHooghe T . World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: IV. Tissue collection, processing, and storage in endometriosis research. Fertil Steril. 2014; 102(5):1244-53. PMC: 4230778. DOI: 10.1016/j.fertnstert.2014.07.1209. View

19.

Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee J, Lotvall J . Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007; 9(6):654-9. DOI: 10.1038/ncb1596. View

20.

Houshdaran S, Zelenko Z, Irwin J, Giudice L . Human endometrial DNA methylome is cycle-dependent and is associated with gene expression regulation. Mol Endocrinol. 2014; 28(7):1118-35. PMC: 4075160. DOI: 10.1210/me.2013-1340. View