Marine Pyridoacridine Alkaloids: Biosynthesis and Biological Activities

Overview

Journal Chem Biodivers

Specialty Biochemistry

Date 2016 Jan 15

PMID 26765351

Citations 7

Authors

Sabrin R M Ibrahim

Gamal A Mohamed

Affiliations

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Abstract

Pyridoacridines are a class of strictly marine-derived alkaloids that constitute one of the largest chemical families of marine alkaloids. During the last few years, both natural pyridoacridines and their analogues have constituted excellent targets for synthetic works. They have been the subject of intense study due to their significant biological activities; cytotoxic, antibacterial, antifungal, antiviral, insecticidal, anti-HIV, and anti-parasitic activities. In the present review, 95 pyridoacridine alkaloids isolated from marine organisms are discussed in term of their occurrence, biosynthesis, biological activities, and structural assignment.

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