Microarray Profiling Analysis of Long Non-coding RNAs Expression in Tendinopathy: Identification for Potential Biomarkers and Mechanisms

Overview

Journal Int J Exp Pathol

Publisher Wiley

Specialty Pathology

Date 2016 Jan 15

PMID 26764085

Citations 6

Authors

Qiang Zhang

Hengan Ge

Yuqing Jiang

Biao Cheng

Dong Zhou

Nanwei Xu

Affiliations

Soon will be listed here.

Abstract

The role of lncRNAs in pathologies of tendinopathy has not been researched so far, this study aims to identify the role and potent mechanism of lncRNAs in tendinopathy with a bioinformatic analysis. The gene profile of GSE26051 based on the platform of Affymetrix Human Genome U133B Array condensed was downloaded from Gene Expression Omnibus. A total of 46 specimens (including 23 normal samples and 23 tendinopathy specimens) were available. Compared with the control samples, differentially expressed genes (DEGs) of tendinopathy was identified the by packages in R. The selected DEGs were further analysed using bioinformatics methods including co-expression and enrichment analysis to detect the potential role of lncRNAs. A total of 40 different expressed lncRNAs were identified. However, most of the identified lncRNAs have not been researched before. And this study only annotate one of the identified lncRNAs successfully, the LOC100507027 (myoregulin), with the potential role in regulating skeletal muscle tissue development and skeletal muscle organ development.

Citing Articles

Advances in non-coding RNA in tendon injuries.

Wang B, Chen Q, Zou X, Zheng P, Zhu J Front Genet. 2024; 15:1396195.

PMID: 38836038 PMC: 11148651. DOI: 10.3389/fgene.2024.1396195.

Analysis of the lncRNA-Associated Competing Endogenous RNA (ceRNA) Network for Tendinopathy.

Huang B, Jing-Jing Y, Dong X, Zhong Z, Liu X Genet Res (Camb). 2022; 2022:9792913.

PMID: 35645614 PMC: 9119753. DOI: 10.1155/2022/9792913.

Screening of key biomarkers of tendinopathy based on bioinformatics and machine learning algorithms.

Zhu Y, Huang J, Ming Y, Zhuang Z, Xia H PLoS One. 2021; 16(10):e0259475.

PMID: 34714891 PMC: 8555777. DOI: 10.1371/journal.pone.0259475.

[Circular RNA expression pattern and competing endogenous RNA network involved in rotator cuff tendinopathy].

Ge Z, Zhou B, Zheng X, Yang M, Lu J, Deng H Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2020; 34(5):608-614.

PMID: 32410429 PMC: 8171857. DOI: 10.7507/1002-1892.201911094.

LncRNA TUG1 promoted osteogenic differentiation through promoting bFGF ubiquitination.

Yu Y, Chen Y, Zheng Y, Weng Q, Zhu S, Zhou D In Vitro Cell Dev Biol Anim. 2020; 56(1):42-48.

PMID: 31907757 DOI: 10.1007/s11626-019-00410-y.

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